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Hallmarks of Aging: Difference between revisions

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| Altered Intercellular Communication
| Altered Intercellular Communication
| Changes in cellular communication leading to inflammation and tissue dysfunction.
| Changes in cellular communication leading to inflammation and tissue dysfunction.
|-
! rowspan="5" |Proposed New Hallmarks
|Compromised Autophagy
|Impaired cellular maintenance through the consumption of own components.
|-
|Splicing Dysregulation
|Impaired RNA construction from DNA, leading to cellular dysfunction.
|-
|Microbiome Disturbance
|Changes in gut microbiome affecting health and aging.
|-
|Altered Mechanical Properties
|Changes in cellular and extracellular structure affecting tissue function.
|-
|Inflammation (Inflammaging)
|Systemic inflammation contributing to aging and related diseases.
|}
|}


== History ==


* '''2013''' The scientific journal ''Cell'' published the article "The Hallmarks of Aging", that was translated to several languages and determined the directions of many studies.{{pmid|23746838}}
==History==
* '''2022''' It was proposed to expand the list of the nine hallmarks of aging with five more.{{pmid|36040386}}<ref>{{cite web|vauthors=Conway J|url=https://www.lifespan.io/news/researchers-propose-five-new-hallmarks-of-aging/|title=Researchers Propose Five New Hallmarks of Aging|work=[[Life Extension Advocacy Foundation|Lifespan.io]]|date=29 August 2022}}</ref>
* '''2023''' In a paywalled review, the authors of a heavily cited paper on the hallmarks of aging update the set of proposed hallmarks after a decade.{{pmid|36599349}} A review with overlapping authors merge or link various hallmarks of cancer with those of aging.{{pmid|36599298}}


== Todo ==
*'''2013''' The scientific journal ''Cell'' published the article "The Hallmarks of Aging", that was translated to several languages and determined the directions of many studies.{{pmid|23746838}}
*'''2022''' It was proposed to expand the list of the nine hallmarks of aging with five more.{{pmid|36040386}}<ref>{{cite web|vauthors=Conway J|url=https://www.lifespan.io/news/researchers-propose-five-new-hallmarks-of-aging/|title=Researchers Propose Five New Hallmarks of Aging|work=[[Life Extension Advocacy Foundation|Lifespan.io]]|date=29 August 2022}}</ref>
*'''2023''' In a paywalled review, the authors of a heavily cited paper on the hallmarks of aging update the set of proposed hallmarks after a decade.{{pmid|36599349}} A review with overlapping authors merge or link various hallmarks of cancer with those of aging.{{pmid|36599298}}


* {{pmid text|23746838}}
==Todo==
* {{pmid text|37329949}}


== References ==
*{{pmid text|23746838}}
*{{pmid text|37329949}}
 
==References==
<references />
<references />
[[Category:Aging]]
[[Category:Aging]]
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