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Hallmarks of Aging: Difference between revisions
→The 14 Hallmarks of Aging (2022)
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! colspan="2" |Hallmark | ! colspan="2" |Hallmark | ||
! Description | ! Description | ||
!Proposed | !Proposed<br>Year | ||
Year | |||
!Category | !Category | ||
|- | |- | ||
| rowspan="6" style="background-color:hsla(195, 100%, 85%);" |'''Molecular | | rowspan="6" style="background-color:hsla(195, 100%, 85%);" |'''Molecular<br>Level''' | ||
| style="text-align:center; background-color:hsla(180, 100%, 85%);" |[[File:DNA Structure+Key+Labelled.pn NoBB.png|frameless|76x76px]] | | style="text-align:center; background-color:hsla(180, 100%, 85%);" |[[File:DNA Structure+Key+Labelled.pn NoBB.png|frameless|76x76px]] | ||
| style="background-color:hsla(180, 100%, 85%);" |'''Genomic instability''' | | style="background-color:hsla(180, 100%, 85%);" |'''Genomic instability''' | ||
| style="background-color:hsla(180, 100%, 85%);" |Accumulation of DNA damage over time leading to cellular dysfunction. | | style="background-color:hsla(180, 100%, 85%);" |Accumulation of DNA damage over time leading to cellular dysfunction. | ||
|2013 | |2013 | ||
| rowspan="5" |'''Primary Hallmarks''' | | rowspan="5" |'''Primary Hallmarks'''<br>(causes damage) | ||
(causes damage) | |||
|- | |- | ||
| style="text-align:center; background-color:hsla(180, 100%, 85%);" |[[File:Telomeres transparent.png|frameless|88x88px]] | | style="text-align:center; background-color:hsla(180, 100%, 85%);" |[[File:Telomeres transparent.png|frameless|88x88px]] | ||
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| style="background-color:hsla(210, 100%, 85%);" | Impaired cellular maintenance through the consumption of own components. | | style="background-color:hsla(210, 100%, 85%);" | Impaired cellular maintenance through the consumption of own components. | ||
| | | | ||
| rowspan="4" |'''Antagonistic Hallmarks''' | | rowspan="4" |'''Antagonistic Hallmarks'''<br>(responses to damage) | ||
(responses to damage) | |||
|- | |- | ||
| rowspan="8" style="background-color:hsla(15, 100%, 85%);" |'''Cellular &<br>Organismal<br>Level''' | | rowspan="8" style="background-color:hsla(15, 100%, 85%);" |'''Cellular &<br>Organismal<br>Level''' | ||
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| style="background-color:hsla(30, 100%, 85%);" |Decline in the regenerative capacity of stem cells affecting tissue repair. | | style="background-color:hsla(30, 100%, 85%);" |Decline in the regenerative capacity of stem cells affecting tissue repair. | ||
|2013 | |2013 | ||
| rowspan="5" |'''Integrative Hallmarks''' | | rowspan="5" |'''Integrative Hallmarks'''<br>(culprits of the phenotype) | ||
(culprits of the phenotype) | |||
|- | |- | ||
| style="text-align:center; background-color:hsla(30, 100%, 85%);" | | | style="text-align:center; background-color:hsla(30, 100%, 85%);" | | ||