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Hallmarks of Aging: Difference between revisions
→The Hallmarks in Detail
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|Telomere shortening is observed during normal aging in humans and mice{{pmid|17876321}}. | |Telomere shortening is observed during normal aging in humans and mice{{pmid|17876321}}. | ||
|Excessive telomere attrition due to stress or genetic factors accelerates cellular aging and the onset of age-related pathologies{{pmid|22426077}}. | |Excessive telomere attrition due to stress or genetic factors accelerates cellular aging and the onset of age-related pathologies{{pmid|22426077}}. | ||
|Maintaining telomere length through telomerase activation or shelterin integrity can delay aging and extend lifespan, as shown in mouse models and suggested by human epidemiological studies{{pmid|21113150}} | |Maintaining telomere length through telomerase activation or shelterin integrity can delay aging and extend lifespan, as shown in mouse models and suggested by human epidemiological studies{{pmid|21113150}}{{pmid|22585399}}. | ||
|Telomere shortening is associated with a variety of human diseases, including pulmonary fibrosis, dyskeratosis congenita, and aplastic anemia, often linked to deficiencies in telomerase or shelterin components{{pmid|22965356}}. | |Telomere shortening is associated with a variety of human diseases, including pulmonary fibrosis, dyskeratosis congenita, and aplastic anemia, often linked to deficiencies in telomerase or shelterin components{{pmid|22965356}}. | ||
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* Overexpression of SIRT1 improves aspects of health during aging but does not increase longevity{{pmid|20975665}} | * Overexpression of SIRT1 improves aspects of health during aging but does not increase longevity{{pmid|20975665}} | ||
* Overexpression of SIRT3 reverse the regenerative capacity of aged stem cells{{pmid|23375372}} | * Overexpression of SIRT3 reverse the regenerative capacity of aged stem cells{{pmid|23375372}} | ||
* Overexpressing ''SIRT6'' in mice have a longer lifespan | * Overexpressing ''SIRT6'' in mice have a longer lifespan{{pmid|22367546}} | ||
|Disorders in histone modification are linked with various aging-related conditions, implicating altered gene expression and protein function{{pmid|22291607}}. | |Disorders in histone modification are linked with various aging-related conditions, implicating altered gene expression and protein function{{pmid|22291607}}. | ||
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