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Hallmarks of Aging: Difference between revisions
→The Hallmarks in Detail
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| style="text-align:center; background-color:hsla(210, 100%, 85%);" |'''Loss of proteostasis'''[[File:Stress signaling.png|frameless|95x95px]] | | style="text-align:center; background-color:hsla(210, 100%, 85%);" |'''Loss of proteostasis'''[[File:Stress signaling.png|frameless|95x95px]] | ||
| style="background-color:hsla(210, 100%, 85%);" | | | style="background-color:hsla(210, 100%, 85%);" |Loss of proteostasis refers to the disruption of the body's ability to regulate its proteins effectively, a process in which chaperones play a crucial role. This encompasses the processes of protein synthesis, folding, transport, and degradation. Chaperones, specialized proteins that assist in the proper folding and stabilization of other proteins, are essential in maintaining proteostasis. As we age, or in certain diseases, the balance of these processes can be disturbed, leading to the accumulation of misfolded or damaged proteins, and a decrease in the ability to produce and maintain healthy proteins. The decline in the efficiency or availability of chaperones contributes to this loss of proteostasis, exacerbating the accumulation of dysfunctional proteins and cellular stress. | ||
| | |Aging and some aging-related diseases are linked to impaired protein homeostasis or proteostasis.{{pmid|19298183}} | ||
| | |Mutant mice that that lack a certain helper chaperone from the heat-shock protein family show accelerated aging.{{pmid|18411298}} | ||
| | |Transgenic worms and flies overexpressing chaperones are long-lived{{pmid|14734639}}{{pmid|12882326}} | ||
| | |Chronic expression of unfolded, misfolded or aggregated proteins contributes to the development of some age-related pathologies, such as Alzheimer’s disease, Parkinson’s disease and cataracts{{pmid|19298183}}. | ||
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| style="text-align:center; background-color:hsla(210, 100%, 85%);" |'''Disabled autophagy'''[[File:Macro-micro-autophagy.gif|frameless|101x101px]] | | style="text-align:center; background-color:hsla(210, 100%, 85%);" |'''Disabled autophagy'''[[File:Macro-micro-autophagy.gif|frameless|101x101px]] | ||