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Hallmarks of Aging: Difference between revisions
→The Hallmarks in Detail
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|Chronic expression of unfolded, misfolded or aggregated proteins contributes to the development of some age-related pathologies, such as Alzheimer’s disease, Parkinson’s disease and cataracts{{pmid|19298183}}. | |Chronic expression of unfolded, misfolded or aggregated proteins contributes to the development of some age-related pathologies, such as Alzheimer’s disease, Parkinson’s disease and cataracts{{pmid|19298183}}. | ||
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| style="text-align:center; background-color:hsla(210, 100%, 85%);" |'''Disabled macroautophagy'''[[File:Macro-micro-autophagy.gif|frameless|101x101px]] | | style="text-align:center; background-color:hsla(210, 100%, 85%);" |'''[[Disabled Macroautophagy|Disabled macroautophagy]]'''[[File:Macro-micro-autophagy.gif|frameless|101x101px]] | ||
| style="background-color:hsla(210, 100%, 85%);" |'''Disabled macroautophagy''', often referred as impaired or dysfunctional autophagy, is a condition where the cellular process of autophagy—specifically the macroautophagy pathway—is disrupted or less effective. Autophagy is a critical cellular process for degrading and recycling damaged organelles, misfolded proteins, and other cellular debris. Macroautophagy involves the engulfment of these unwanted materials into vesicles called autophagosomes, which then fuse with lysosomes where the contents are degraded and recycled. When macroautophagy is disabled or impaired, cells accumulate damaged proteins and organelles, leading to cellular dysfunction and contributing to various diseases, particularly those related to aging and neurodegeneration. This loss of a crucial cellular "cleanup" mechanism can result in increased oxidative stress, disrupted cellular homeostasis, and an acceleration of the aging process. | | style="background-color:hsla(210, 100%, 85%);" |'''Disabled macroautophagy''', often referred as impaired or dysfunctional autophagy, is a condition where the cellular process of autophagy—specifically the macroautophagy pathway—is disrupted or less effective. Autophagy is a critical cellular process for degrading and recycling damaged organelles, misfolded proteins, and other cellular debris. Macroautophagy involves the engulfment of these unwanted materials into vesicles called autophagosomes, which then fuse with lysosomes where the contents are degraded and recycled. When macroautophagy is disabled or impaired, cells accumulate damaged proteins and organelles, leading to cellular dysfunction and contributing to various diseases, particularly those related to aging and neurodegeneration. This loss of a crucial cellular "cleanup" mechanism can result in increased oxidative stress, disrupted cellular homeostasis, and an acceleration of the aging process. | ||