Coenzyme Q10 (CoQ10): Difference between revisions

Data on the metabolism of CoQ₁₀ in animals and humans are limited.<ref name="Zmitek" /> A study with ¹⁴C-labeled CoQ₁₀ in rats showed most of the radioactivity in the liver two hours after oral administration when the peak plasma radioactivity was observed, but CoQ₉ (with only 9 isoprenyl units) is the predominant form of coenzyme Q in rats.<ref>{{cite book |first1=H. |last1=Kishi |first2=N. |last2=Kanamori |first3=S. |last3=Nisii |first4=E. |last4=Hiraoka |first5=T. |last5=Okamoto |first6=T. |last6=Kishi |chapter=Metabolism and Exogenous Coenzyme Q₁₀ in vivo and Bioavailability of Coenzyme Q₁₀ Preparations in Japan |title=Biomedical and Clinical Aspects of Coenzyme Q |pages=131–142 |publisher=Elsevier |location=Amsterdam |year=1964}}</ref> It appears that CoQ₁₀ is metabolised in all tissues, while a major route for its elimination is biliary and fecal excretion. After the withdrawal of CoQ₁₀ supplementation, the levels return to normal within a few days, irrespective of the type of formulation used.<ref name="Ozawa" />