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Chronic Inflammation (Inflammaging): Difference between revisions
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===The Basis of Inflammaging=== | ===The Basis of Inflammaging=== | ||
Inflammaging is driven by several factors, including: | Inflammaging is driven by several factors, including: | ||
*'''Cellular Senescence''': Senescent cells accumulate with age and secrete inflammatory cytokines, chemokines, and proteases, known collectively as the senescence-associated secretory phenotype (SASP). This contributes significantly to the chronic inflammatory state. | *'''[[Cellular Senescence]]''': Senescent cells accumulate with age and secrete inflammatory cytokines, chemokines, and proteases, known collectively as the senescence-associated secretory phenotype (SASP). This contributes significantly to the chronic inflammatory state. | ||
*'''Immune System Dysregulation''': Aging is associated with changes in the immune system, a phenomenon known as immunosenescence, which can lead to an imbalanced immune response and prolonged inflammatory activity. | *'''Immune System Dysregulation''': Aging is associated with changes in the immune system, a phenomenon known as immunosenescence, which can lead to an imbalanced immune response and prolonged inflammatory activity. | ||
*'''Genetic Factors''': Certain genetic predispositions can influence the extent and impact of inflammaging. | *'''Genetic Factors''': Certain genetic predispositions can influence the extent and impact of inflammaging. | ||
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*'''Cardiovascular Diseases''': Chronic inflammation contributes to the development of atherosclerosis, hypertension, and other cardiovascular conditions. | *'''Cardiovascular Diseases''': Chronic inflammation contributes to the development of atherosclerosis, hypertension, and other cardiovascular conditions. | ||
*'''Metabolic Disorders''': Inflammation is a critical factor in the pathogenesis of insulin resistance, type 2 diabetes, and metabolic syndrome. | *'''Metabolic Disorders''': Inflammation is a critical factor in the pathogenesis of insulin resistance, type 2 diabetes, and metabolic syndrome. | ||
*'''Neurodegenerative | *'''[[Neurodegenerative Disorders]]''': Inflammatory processes are involved in the progression of Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. | ||
*'''Cancer''': Chronic inflammation can lead to DNA damage, promote tumor growth, and suppress immune surveillance. | *'''Cancer''': Chronic inflammation can lead to DNA damage, promote tumor growth, and suppress immune surveillance. | ||
*'''Musculoskeletal Disorders''': Conditions like osteoarthritis and sarcopenia are associated with increased inflammatory activity. | *'''Musculoskeletal Disorders''': Conditions like osteoarthritis and sarcopenia are associated with increased inflammatory activity. | ||
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*'''Nuclear Factor-kappa B (NF-κB) Pathway''': NF-κB is a key regulator of inflammatory responses. Its persistent activation is a common feature of chronic inflammation and aging. | *'''Nuclear Factor-kappa B (NF-κB) Pathway''': NF-κB is a key regulator of inflammatory responses. Its persistent activation is a common feature of chronic inflammation and aging. | ||
*'''Inflammasomes''': Inflammasomes are protein complexes that promote the production of pro-inflammatory cytokines such as IL-1β and IL-18, contributing to the chronic inflammatory milieu. | *'''Inflammasomes''': Inflammasomes are protein complexes that promote the production of pro-inflammatory cytokines such as IL-1β and IL-18, contributing to the chronic inflammatory milieu. | ||
*'''Dysbiosis''': Alterations in the gut microbiome can lead to increased intestinal permeability and a chronic systemic inflammatory state. | *'''[[Dysbiosis]]''': Alterations in the gut microbiome can lead to increased intestinal permeability and a chronic systemic inflammatory state. | ||
*'''Mitochondrial Dysfunction''': Dysfunctional mitochondria can release reactive oxygen species and other signals that promote inflammatory responses. | *'''[[Mitochondrial Dysfunction]]''': Dysfunctional mitochondria can release reactive oxygen species and other signals that promote inflammatory responses. | ||
===Therapeutic Strategies=== | ===Therapeutic Strategies=== | ||
Several strategies are being investigated to mitigate inflammaging and its impact on age-related diseases: | Several strategies are being investigated to mitigate inflammaging and its impact on age-related diseases: | ||