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Loss of Proteostasis: Difference between revisions
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'''Loss of Proteostasis''' is one of the primary hallmarks of aging, signifying the decline in the cell's ability to regulate protein balance. Proteostasis encompasses all aspects of protein metabolism, including the synthesis, folding, trafficking, and degradation of proteins. Efficient proteostasis is vital for maintaining cellular function and homeostasis, as proteins are integral components of all cellular processes. However, as organisms age, the proteostasis network becomes less efficient, leading to the accumulation of damaged and misfolded proteins, which can form toxic aggregates and disrupt cellular functions. | '''Loss of Proteostasis''' is one of the primary hallmarks of aging, signifying the decline in the cell's ability to regulate protein balance. Proteostasis encompasses all aspects of protein metabolism, including the synthesis, folding, trafficking, and degradation of proteins. Efficient proteostasis is vital for maintaining cellular function and homeostasis, as proteins are integral components of all cellular processes. However, as organisms age, the proteostasis network becomes less efficient, leading to the accumulation of damaged and misfolded proteins, which can form toxic aggregates and disrupt cellular functions. | ||
==The Proteostasis Network== | ==The Proteostasis Network== | ||