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[[File:Food level, fecundity and longevity.jpg|thumb|Food level, fecundity and longevity. Median life span and fecundity are negatively affected by a very low nutrient concentration in higher eukaryotes. However, life span but not fecundity is optimized by DR.{{pmid|20395504}}]] | |||
'''Calorie Restriction''' (CR), also known as '''calorie restriction''' or '''dietary restriction''', refers to a diet that reduces the intake of chemically bound energy from foods by 10 to 50 percent compared to ''ad libitum'' ("at will") nutrition. The goal is to achieve a higher life expectancy or at least delayed aging or health-promoting effects{{pmid|21663754}}{{pmid|19104499}}, without leading to malnutrition. | '''Calorie Restriction''' (CR), also known as '''calorie restriction''' or '''dietary restriction''', refers to a diet that reduces the intake of chemically bound energy from foods by 10 to 50 percent compared to ''ad libitum'' ("at will") nutrition. The goal is to achieve a higher life expectancy or at least delayed aging or health-promoting effects{{pmid|21663754}}{{pmid|19104499}}, without leading to malnutrition. | ||