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Pathway: Difference between revisions
→Longevity-Relevant Biological Pathways
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!Pathway | !Pathway | ||
!Description | !Description | ||
! Significance in Longevity | !Significance in Longevity | ||
!Notable Examples | !Notable Examples | ||
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|Involves the mechanistic target of rapamycin, a key regulator of cell growth, proliferation, and survival. | |Involves the mechanistic target of rapamycin, a key regulator of cell growth, proliferation, and survival. | ||
|Inhibition of mTOR signaling has been shown to extend lifespan in yeast, worms, flies, and mice. | |Inhibition of mTOR signaling has been shown to extend lifespan in yeast, worms, flies, and mice. | ||
| Rapamycin | |Rapamycin | ||
|- | |- | ||
|Sirtuin Pathways | |Sirtuin Pathways | ||
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|Central energy sensor, important for maintaining energy homeostasis. | |Central energy sensor, important for maintaining energy homeostasis. | ||
|Activation of AMPK has been linked to extended lifespan and improved metabolic health. | |Activation of AMPK has been linked to extended lifespan and improved metabolic health. | ||
| Metformin | |Metformin | ||
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|NRF2 Pathway | |NRF2 Pathway | ||
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|Sulforaphane | |Sulforaphane | ||
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| Autophagy Pathways | |Autophagy Pathways | ||
| Responsible for the degradation and recycling of cellular components. | |Responsible for the degradation and recycling of cellular components. | ||
|Enhanced autophagy is associated with longevity and protection against neurodegenerative diseases. | |Enhanced autophagy is associated with longevity and protection against neurodegenerative diseases. | ||
|Caloric restriction | |Caloric restriction | ||
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|DNA Repair Pathways | |||
|Involved in the detection and repair of damage to the DNA. | |||
|Efficient DNA repair mechanisms are essential for longevity and reducing age-related diseases. | |||
|BRCA1/BRCA2 in DNA repair | |||
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|Telomere Maintenance | |||
|Involves the protection and extension of telomeres, the end parts of chromosomes. | |||
|Telomere length and maintenance are closely associated with aging and cellular lifespan. | |||
|Telomerase activation | |||
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|Reactive Oxygen Species (ROS) Management | |||
|Balances the production and detoxification of reactive oxygen species. | |||
|Effective management of ROS is linked to increased lifespan and reduced oxidative stress. | |||
|Antioxidants like glutathione | |||
|} | |} | ||