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 === Limitations and Considerations ===
-While antioxidants are beneficial, their supplementation is not without limitations. Excessive intake of some antioxidants can be harmful, and the balance between antioxidants and ROS is crucial. The concept of antioxidant supplementation is complex, and more research is needed to fully understand its implications for health and aging.
+While antioxidants in general are beneficial, their supplementation is not without limitations. Antioxidant supplements have not shown preventive effects and may be harmful with unwanted consequences to our health. The optimal source of antioxidants seems to come from our diet, not from antioxidant supplements.
-A 2007 meta-analysis finds that in studies with a low risk of bias (randomization, blinding, follow-up), some popular antioxidant supplements (vitamin A, beta carotene, and vitamin E) may increase mortality risk (although studies more prone to bias reported the reverse).{{pmid|17327526}}
+Older observational studies and some randomized clinical trials with high risks of systematic errors ('bias') have suggested that antioxidant supplements may improve health and prolong life. A number of randomized clinical trials with adequate methodologies observed neutral or negative results of antioxidant supplements. Recently completed large randomized clinical trials with low risks of bias and systematic reviews of randomized clinical trials taking systematic errors ('bias') and risks of random errors ('play of chance') into account have shown that antioxidant supplements do not seem to prevent cancer, cardiovascular diseases, or death. Even more, beta-carotene, vitamin A, and vitamin E may increase mortality.{{pmid|17327526}} Some recent large observational studies now support these findings. According to recent dietary guidelines, there is no evidence to support the use of antioxidant supplements in the primary prevention of chronic diseases or mortality.{{pmid|22419320}}{{pmid|24241129}}
+A 2007 meta-analysis finds that in studies with a low risk of bias (randomization, blinding, follow-up), some popular antioxidant supplements (vitamin A, beta carotene, and vitamin E) may increase mortality risk (although studies more prone to bias reported the reverse).
 == Conclusion ==