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Disabled Macroautophagy: Difference between revisions
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When macroautophagy is disabled or impaired: | When macroautophagy is disabled or impaired: | ||
*'''Accumulation of Damaged Components''': Cells accumulate damaged proteins and organelles, which can interfere with normal cellular functions and lead to cellular aging and death. | *'''Accumulation of Damaged Components''': Cells accumulate damaged proteins and organelles, which can interfere with normal cellular functions and lead to cellular aging and death. | ||
*'''Increased Oxidative Stress''': Impaired clearance of damaged mitochondria leads to increased production of reactive oxygen species (ROS), contributing to oxidative stress and further damaging cellular components. | *'''Increased [[Oxidative Stress]]''': Impaired clearance of damaged mitochondria leads to increased production of reactive oxygen species (ROS), contributing to oxidative stress and further damaging cellular components. | ||
*'''Disease Progression''': Disabled macroautophagy has been implicated in the progression of various diseases, including neurodegenerative diseases (like Alzheimer's and Parkinson's), cancer, and metabolic disorders. | *'''Disease Progression''': Disabled macroautophagy has been implicated in the progression of various diseases, including neurodegenerative diseases (like Alzheimer's and Parkinson's), cancer, and metabolic disorders. | ||
*'''Aging''': Impaired autophagy is associated with many aging-related phenotypes and may contribute to the aging process itself by allowing the accumulation of cellular damage over time. | *'''Aging''': Impaired autophagy is associated with many aging-related phenotypes and may contribute to the aging process itself by allowing the accumulation of cellular damage over time. | ||