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== | == Biomarkers for Biological Age Estimation == | ||
{| class="wikitable" | {| class="wikitable" | ||
! Organ system | ! Organ system | ||
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| | | | ||
|} | |} | ||
== Biomarkers 2 == | |||
The common aging biomarkers of four methods in different systems. | |||
{| class="wikitable" | |||
! colspan="1" rowspan="1" |System | |||
! colspan="1" rowspan="1" |MLR | |||
! colspan="1" rowspan="1" |PCA | |||
! colspan="1" rowspan="1" |KDM | |||
! colspan="1" rowspan="1" |Deep learning | |||
|- | |||
| colspan="1" rowspan="17" |Cardiovascular system | |||
| colspan="1" rowspan="1" |<nowiki>SBP{{pmid|23213031}}{{pmid|5841151}}{{pmid|3226152}}{{pmid|950448}}{{pmid|6667707}}{{pmid|17889950}}{{pmid|23642770}}{{pmid|28110151}}{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>SBP{{pmid|23213031}}{{pmid|3226152}}{{pmid|2737197}}{{pmid|2282902}}{{pmid|8803500}}{{pmid|12634284}}{{pmid|12672981}}{{pmid|17921421}}{{pmid|18840798}}{{pmid|18597867}}{{pmid|22433233}}{{pmid|28110151}}{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>SBP{{pmid|23213031}}{{pmid|26150497}}{{pmid|28110151}}{{pmid|28958059}}{{pmid|28977464}}{{pmid|30999227}}{{pmid|30899733}}{{pmid|31566204}}{{pmid|32946548}}{{pmid|34038024}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>DBP{{pmid|17889950}}{{pmid|23642770}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>DBP{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>DBP{{pmid|27216811}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Pulse pressure{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Pulse pressure{{pmid|29188884}}{{pmid|24522464}}{{pmid|19940465}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Mean arterial pressure{{pmid|28203066}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Pulse{{pmid|3226152}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Pulse{{pmid|3226152}}{{pmid|2737197}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Pulse wave velocity{{pmid|6667707}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Heart rate{{pmid|2282902}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Intima-media thickness{{pmid|24659482}}{{pmid|19940465}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |Minimum intima-media | |||
thickness<nowiki>{{pmid|29188884}}</nowiki><nowiki>{{pmid|24522464}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>End diastolic velocity{{pmid|19940465}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>mitral valve E/A peak{{pmid|29188884}}{{pmid|19940465}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>MVEL{{pmid|19940465}}, MVES{{pmid|24522464}}, MVEA{{pmid|24659482}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Atherosclerosis index{{pmid|2737197}}{{pmid|2282902}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>NT-proBNP{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Cardiac troponin I{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Creatine phosphokinase{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Homocysteine{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="6" |Respiratory | |||
system | |||
| colspan="1" rowspan="1" |<nowiki>FVC{{pmid|3226152}}{{pmid|17889950}}{{pmid|23642770}}{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>FVC{{pmid|3226152}}{{pmid|2737197}}{{pmid|2282902}}{{pmid|8803500}}{{pmid|12634284}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>FVC{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>FEV1{{pmid|23213031}}{{pmid|950448}}{{pmid|7162237}}{{pmid|17889950}}{{pmid|23642770}}{{pmid|28110151}}{{pmid|30899733}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>FEV1{{pmid|23213031}}{{pmid|12634284}}{{pmid|12672981}}{{pmid|17921421}}{{pmid|18840798}}{{pmid|18597867}}{{pmid|22433233}}{{pmid|28110151}}{{pmid|30899733}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>FEV1{{pmid|23213031}}{{pmid|26150497}}{{pmid|28110151}}{{pmid|28958059}}{{pmid|28977464}}{{pmid|30899733}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Vital capacity{{pmid|5841151}}{{pmid|6667707}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |Maximal midexpiratory | |||
flow rate 75/25<nowiki>{{pmid|24522464}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>VO2 max{{pmid|18597867}}{{pmid|22433233}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Chest radiography{{pmid|33744131}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="9" |Nervous system | |||
| colspan="1" rowspan="1" |<nowiki>MMSE{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>MMSE{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>MMSE{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Digital symbol test{{pmid|6667707}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Digital symbol test{{pmid|24659482}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Numeric memory{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Numeric memory{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Associated memory{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Associated memory{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Topological memory{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Topological memory{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Short-time memory{{pmid|6610563}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Concentration{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Concentration{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Intellectuality -mental defect{{pmid|6667707}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Trail making test{{pmid|29188884}}{{pmid|24522464}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="15" |Endocrine metabolic system | |||
| colspan="1" rowspan="1" |<nowiki>Glucose{{pmid|17889950}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Glucose{{pmid|8803500}}{{pmid|12672981}}{{pmid|28203066}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Glucose{{pmid|28977464}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Glucose{{pmid|27191382}}{{pmid|29340580}}{{pmid|30644411}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>HBA1C{{pmid|23213031}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>HBA1C{{pmid|23213031}}{{pmid|18597867}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>HBA1C{{pmid|23213031}}{{pmid|26150497}}{{pmid|28958059}}{{pmid|30999227}}{{pmid|31566204}}{{pmid|32946548}}{{pmid|31693736}}{{pmid|34038024}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>HBA1C{{pmid|30644411}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>C-peptide{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Insulin{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Triglyceride{{pmid|950448}}{{pmid|17889950}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Triglyceride{{pmid|2282902}}{{pmid|28203066}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Triglyceride{{pmid|32946548}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Triglyceride{{pmid|29340580}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>TC{{pmid|23213031}}{{pmid|5841151}}{{pmid|3226152}}{{pmid|950448}}{{pmid|7162237}}{{pmid|17889950}}{{pmid|23642770}}{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>TC{{pmid|23213031}}{{pmid|3226152}}{{pmid|8803500}}{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>TC{{pmid|23213031}}{{pmid|26150497}}{{pmid|28110151}}{{pmid|28958059}}{{pmid|28977464}}{{pmid|31566204}}{{pmid|32946548}}{{pmid|34038024}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>TC{{pmid|27191382}}{{pmid|29340580}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>HDL{{pmid|17889950}}, LDL{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>HDL{{pmid|28203066}}, LDL{{pmid|18597867}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>HDL{{pmid|29340580}}{{pmid|34453631}},LDL{{pmid|29340580}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Apolipoprotein A1 and B{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>TSH{{pmid|17889950}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>TSH{{pmid|27216811}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Testosterone{{pmid|17889950}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Testosterone{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Vitamin D{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Vitamin D{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Vitamin D{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Vitamin D{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Calcium{{pmid|27216811}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Calcium{{pmid|29340580}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Potassium{{pmid|29340580}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Sodium{{pmid|29340580}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Inorganic phosphorus{{pmid|27216811}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="8" |Urinary system | |||
| colspan="1" rowspan="1" |<nowiki>Urea{{pmid|23213031}}{{pmid|3226152}}{{pmid|950448}}{{pmid|23642770}}{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Urea{{pmid|23213031}}{{pmid|3226152}}{{pmid|2737197}}{{pmid|2282902}}{{pmid|8803500}}{{pmid|12634284}}{{pmid|17921421}}{{pmid|18840798}}{{pmid|18597867}}{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Urea{{pmid|23213031}}{{pmid|26150497}}{{pmid|27216811}}{{pmid|28110151}}{{pmid|30999227}}{{pmid|31566204}}{{pmid|32946548}}{{pmid|31693736}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Urea{{pmid|27191382}}{{pmid|29340580}}{{pmid|30644411}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Creatinine{{pmid|23213031}}{{pmid|17889950}}{{pmid|23642770}}{{pmid|28110151}}{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Creatinine{{pmid|28110151}}{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Creatinine{{pmid|23213031}}{{pmid|26150497}}{{pmid|27216811}}{{pmid|28958059}}{{pmid|30999227}}{{pmid|31566204}}{{pmid|32946548}}{{pmid|31693736}}{{pmid|34038024}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Creatinine{{pmid|29340580}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>eGFR{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>eGFR{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>eGFR{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Uric acid{{pmid|30999227}}{{pmid|31693736}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Uric acid{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Cystatin C{{pmid|29188884}}{{pmid|24659482}}{{pmid|24522464}}{{pmid|19940465}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Cystatin C{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Creatinine clearance{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Urine specific gravity{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Urine pH{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="12" |Digestive system | |||
| colspan="1" rowspan="1" |<nowiki>ALT{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>ALT{{pmid|8803500}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>ALT{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>AST{{pmid|3226152}}{{pmid|23642770}}{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>AST{{pmid|3226152}}{{pmid|2737197}}{{pmid|2282902}}{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>AST{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>AST{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>ALP{{pmid|23213031}}{{pmid|950448}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>ALP{{pmid|23213031}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>ALP{{pmid|23213031}}{{pmid|26150497}}{{pmid|27216811}}{{pmid|28958059}}{{pmid|30999227}}{{pmid|31693736}}{{pmid|34038024}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>ALP{{pmid|27191382}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Total protein{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Total protein{{pmid|27216811}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Total protein{{pmid|29340580}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Albumin{{pmid|23213031}}{{pmid|3226152}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Albumin{{pmid|23213031}}{{pmid|3226152}}{{pmid|12634284}}{{pmid|17921421}}{{pmid|18840798}}{{pmid|18597867}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Albumin{{pmid|23213031}}{{pmid|26150497}}{{pmid|27216811}}{{pmid|28958059}}{{pmid|30999227}}{{pmid|31566204}}{{pmid|32946548}}{{pmid|31693736}}{{pmid|34038024}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Albumin{{pmid|27191382}}{{pmid|29340580}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>A/G{{pmid|3226152}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>A/G{{pmid|3226152}}{{pmid|12634284}}{{pmid|12672981}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Total bilirubin{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Total bilirubin{{pmid|29340580}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Direct bilirubin{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Amylase{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Lactate dehydrogenase{{pmid|7162237}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Lactate dehydrogenase{{pmid|2282902}}{{pmid|8803500}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Alpha 2 globulin{{pmid|27191382}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |Gamma glutamyl | |||
transpeptidase<nowiki>{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="21" |Hematologic System | |||
| colspan="1" rowspan="1" |<nowiki>Red blood cell{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Red blood cell{{pmid|12634284}}{{pmid|18840798}}{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Red blood cell{{pmid|30899733}}{{pmid|32946548}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Red blood cell{{pmid|27191382}}{{pmid|29340580}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |Red blood cell volume | |||
distribution width<nowiki>{{pmid|30999227}}</nowiki> | |||
| colspan="1" rowspan="1" |Red blood cell volume | |||
distribution width<nowiki>{{pmid|27191382}}</nowiki><nowiki>{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Hematocrit{{pmid|12634284}}{{pmid|17921421}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Hematocrit{{pmid|27191382}}{{pmid|29340580}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |Mean corpuscular | |||
volume<nowiki>{{pmid|30999227}}</nowiki><nowiki>{{pmid|31566204}}</nowiki><nowiki>{{pmid|31693736}}</nowiki> | |||
| colspan="1" rowspan="1" |Mean corpuscular | |||
volume<nowiki>{{pmid|29340580}}</nowiki><nowiki>{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |Mean corpuscular | |||
hemoglobin<nowiki>{{pmid|12672981}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Mean corpuscular hemoglobin concentration{{pmid|29340580}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Hemoglobin{{pmid|3226152}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Hemoglobin{{pmid|3226152}}{{pmid|2737197}}{{pmid|2282902}}{{pmid|8803500}}{{pmid|12634284}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Hemoglobin{{pmid|27216811}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Hemoglobin{{pmid|29340580}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>White blood cell{{pmid|30999227}}{{pmid|31566204}}{{pmid|31693736}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>White blood cell{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Granulocytes{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Neutrophils{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Basophils{{pmid|34453631}}, Eosinophils{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Lymphocytes{{pmid|30999227}}{{pmid|31566204}}{{pmid|31693736}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Lymphocytes{{pmid|27191382}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Monocytes{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Monocytes{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Monocytes{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Monocytes{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Platelet{{pmid|32946548}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Platelet{{pmid|29340580}}{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Mean platelet volume{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Platelet distribution width{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |Erythrocyte | |||
| colspan="1" rowspan="1" |Erythrocyte | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>sedimentation rat{{pmid|950448}}{{pmid|17889950}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>sedimentation rat{{pmid|18597867}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>D-dimer{{pmid|24659482}}</nowiki> | |||
Fibrinogen<nowiki>{{pmid|19940465}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>D-dimer{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Ferritin{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Ferritin{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Ferritin{{pmid|28110151}}{{pmid|32946548}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Ferritin{{pmid|30644411}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Fransferrin{{pmid|32946548}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="6" |Sensory system | |||
| colspan="1" rowspan="1" |<nowiki>Visual accommodation{{pmid|6667707}}{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Visual accommodation{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Visual reaction time{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Visual reaction time{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Visual acuity{{pmid|5841151}}{{pmid|3226152}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Visual acuity{{pmid|3226152}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Hearing{{pmid|5841151}}{{pmid|7162237}}{{pmid|6667707}}{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Hearing{{pmid|18597867}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Hearing{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Vibrotactile{{pmid|5841151}}{{pmid|6610563}}{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Vibrotactile{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |Retinal photos | |||
|- | |||
| colspan="1" rowspan="4" |Inflammatory index | |||
| colspan="1" rowspan="1" |<nowiki>CRP{{pmid|23213031}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>CRP{{pmid|23213031}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>CRP{{pmid|23213031}}{{pmid|26150497}}{{pmid|28958059}}{{pmid|28977464}}{{pmid|30999227}}{{pmid|31566204}}{{pmid|32946548}}{{pmid|31693736}}{{pmid|34038024}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>CRP{{pmid|34453631}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Cytomegalovirus optical density{{pmid|23213031}}</nowiki> | |||
| colspan="1" rowspan="1" |Cytomegalovirus | |||
optical density<nowiki>{{pmid|23213031}}</nowiki> | |||
| colspan="1" rowspan="1" |Cytomegalovirus | |||
optical density<nowiki>{{pmid|23213031}}</nowiki><nowiki>{{pmid|26150497}}</nowiki><nowiki>{{pmid|31566204}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="2" | | |||
| colspan="1" rowspan="2" | | |||
| colspan="1" rowspan="1" |<nowiki>Interleukin-6{{pmid|28977464}}</nowiki> | |||
| colspan="1" rowspan="2" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>P-selectin{{pmid|28977464}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="5" |Motion index | |||
| colspan="1" rowspan="1" |<nowiki>Grip strength{{pmid|5841151}}{{pmid|6610563}}{{pmid|31179487}}{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Grip strength{{pmid|22433233}}{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Grip strength{{pmid|31179487}}{{pmid|20005245}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Vertical jump{{pmid|22433233}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Timed up and go test{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Timed up and go test{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Timed up and go test{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Chair rise time{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Chair rise time{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Chair rise time{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>1-week physical activity{{pmid|29581467}}{{pmid|31388024}}</nowiki> | |||
|- | |||
| colspan="1" rowspan="9" |Body morphology index | |||
| colspan="1" rowspan="1" |<nowiki>WC{{pmid|23642770}}{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>WC{{pmid|18597867}}{{pmid|22433233}}{{pmid|28110151}}{{pmid|28203066}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>WC{{pmid|28110151}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Waist-to-hip ratio{{pmid|17889950}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Waist-to-height ratio{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Waist-to-height ratio{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Waist-to-height ratio{{pmid|30899733}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Body mass index{{pmid|17889950}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Weight{{pmid|6667707}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Height{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Height{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Height{{pmid|31179487}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Body fat{{pmid|17889950}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" |<nowiki>Body fat{{pmid|18597867}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |<nowiki>Lean body mass{{pmid|17889950}}{{pmid|23642770}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |<nowiki>Soft lean mass{{pmid|22433233}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |Genetic index | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |Terminal telomere restriction | |||
fragment<nowiki>{{pmid|24659482}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|- | |||
| colspan="1" rowspan="1" |Genetic index | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" |Terminal telomere restriction | |||
fragment<nowiki>{{pmid|24659482}}</nowiki> | |||
| colspan="1" rowspan="1" | | |||
| colspan="1" rowspan="1" | | |||
|} | |||
SBP, systolic blood pressure; DBP, diastolic blood pressure; NT-proBNP, N-terminal pro brain natriuretic peptide; MVEA, mitral annulus peak E anterior wall; MVEL, mitral valve annulus lateral wall of peak velocity of early filling; MVES, mitral valve annulus ventricular septum of the peak velocity of early filling; FEV1, forced expiratory volume in 1.0 s; FVC, forced vital capacity; MMSE, mini-mental state examination; eGFR, estimated glomerular filtration rat; HBA1C, glycosylated hemoglobin; HDL, high density lipoprotein; LDL, low density lipoprotein; TSH, thyroid stimulating hormone; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; ALP, alkaline ''phosphatase; A/G, ratio of albumin to globulin; CRP, c-reactive protein; WC, waist circumference''. | |||
== Further Reading == | == Further Reading == |