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Resveratrol: Difference between revisions
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=== Anti-Inflammatory Effects === <!--T:13--> | === Anti-Inflammatory Effects === <!--T:13--> | ||
The anti-inflammatory effects of resveratrol are significant in the context of aging. Chronic inflammation is implicated in numerous age-related conditions, and resveratrol’s ability to modulate inflammatory responses could be pivotal in mitigating the impacts of such conditions. | The anti-inflammatory effects of resveratrol are significant in the context of aging. Chronic inflammation is implicated in numerous age-related conditions, and resveratrol’s ability to modulate inflammatory responses could be pivotal in mitigating the impacts of such conditions. | ||
=== Sirtuin Activation and Regulation === <!--T:15--> | === Sirtuin Activation and Regulation === <!--T:15--> | ||
Resveratrol is known to activate [[Sirtuins|sirtuins]], a family of proteins associated with aging and longevity. Sirtuins regulate various cellular processes, including DNA repair, metabolism, and stress resistance, and are believed to extend lifespan by promoting cellular stability and survival. | Resveratrol is known to activate [[Sirtuins|sirtuins]], a family of proteins associated with aging and longevity. Sirtuins regulate various cellular processes, including DNA repair, metabolism, and stress resistance, and are believed to extend lifespan by promoting cellular stability and survival. | ||
=== Impact on Telomeres === <!--T:17--> | === Impact on Telomeres === <!--T:17--> | ||
[[Telomeres]] are the protective caps at the ends of chromosomes that shorten as cells divide. Resveratrol is suggested to influence telomere length and function, potentially delaying [[Cellular Senescence|cellular senescence]] and extending the lifespan of cells. | [[Telomeres]] are the protective caps at the ends of chromosomes that shorten as cells divide. Resveratrol is suggested to influence telomere length and function, potentially delaying [[Cellular Senescence|cellular senescence]] and extending the lifespan of cells. | ||
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*'''Trans-resveratrol''' is the most abundant and biologically active form of resveratrol in plants. It is the form that has been most studied in scientific research and is thought to be responsible for the majority of the health benefits associated with resveratrol. | *'''Trans-resveratrol''' is the most abundant and biologically active form of resveratrol in plants. It is the form that has been most studied in scientific research and is thought to be responsible for the majority of the health benefits associated with resveratrol. | ||
*'''Cis-resveratrol''' is less abundant in nature and less biologically active than trans-resveratrol. However, it has still been shown to have some health benefits, such as [[Antioxidant|antioxidant]] and anti-inflammatory effects. | *'''Cis-resveratrol''' is less abundant in nature and less biologically active than trans-resveratrol. However, it has still been shown to have some health benefits, such as [[Antioxidant|antioxidant]] and anti-inflammatory effects. | ||
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===Trans-Resveratrol=== <!--T:37--> | ===Trans-Resveratrol=== <!--T:37--> | ||
Trans-resveratrol unfortunately suffers from '''poor bioavailability''' and '''water solubility'''. Its solubility in water is less than 0.05 mg/ml. Studies have indicated varying plasma concentrations after repeated doses of resveratrol: | Trans-resveratrol unfortunately suffers from '''poor bioavailability''' and '''water solubility'''. Its solubility in water is less than 0.05 mg/ml. Studies have indicated varying plasma concentrations after repeated doses of resveratrol: | ||
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=== Recommended Dosage=== <!--T:69--> | === Recommended Dosage=== <!--T:69--> | ||
The recommended dosage for adults is generally between 150 to 500 mg per day, although this can vary based on individual health conditions and specific product formulations. In a study {{#pmid:20935227|pmid20935227}}, participants received resveratrol for 29 days at doses of up to 5.0g per day. | The recommended dosage for adults is generally between 150 to 500 mg per day, although this can vary based on individual health conditions and specific product formulations. In a study {{#pmid:20935227|pmid20935227}}, participants received resveratrol for 29 days at doses of up to 5.0g per day. | ||
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===Safety === <!--T:53--> | ===Safety === <!--T:53--> | ||
Resveratrol is generally considered safe when taken in recommended amounts, but excessive consumption can lead to side effects. In a study, it was found to be safe as no severe adverse reactions were observed based on clinical, biochemical, or hematological analyses. | Resveratrol is generally considered safe when taken in recommended amounts, but excessive consumption can lead to side effects. In a study, it was found to be safe as no severe adverse reactions were observed based on clinical, biochemical, or hematological analyses. | ||
===Side Effects=== <!--T:55--> | ===Side Effects=== <!--T:55--> | ||
Some people may experience gastrointestinal issues, headaches, or a feeling of jitteriness. In the mentioned study {{#pmid:20935227|pmid20935227}}, the majority of adverse events in the higher doses (2.5g and 5.0g) were gastrointestinal symptoms, including nausea, flatulence, abdominal discomfort, and diarrhea. Symptoms typically began 2-4 days into the regimen and improved as the day progressed but would return after the next dose. They resolved within 2 days of completing the 29-day regimen. | Some people may experience gastrointestinal issues, headaches, or a feeling of jitteriness. In the mentioned study {{#pmid:20935227|pmid20935227}}, the majority of adverse events in the higher doses (2.5g and 5.0g) were gastrointestinal symptoms, including nausea, flatulence, abdominal discomfort, and diarrhea. Symptoms typically began 2-4 days into the regimen and improved as the day progressed but would return after the next dose. They resolved within 2 days of completing the 29-day regimen. | ||
== See Also == <!--T:57--> | == See Also == <!--T:57--> | ||
* Wikipedia - [[Wikipedia:Resveratrol|Resveratrol]] | * Wikipedia - [[Wikipedia:Resveratrol|Resveratrol]] | ||
* [[Caloric Restriction]] | * [[Caloric Restriction]] | ||
== Further Reading == <!--T:59--> | == Further Reading == <!--T:59--> | ||
*{{pmid text|34336123}} | *{{pmid text|34336123}} | ||