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Cellular Senescence: Difference between revisions
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However, it's important to note that while the absolute number of senescent cells might decline in advanced age, their relative impact on tissue function and inflammation can remain significant. The presence of even a small proportion of senescent cells can disrupt tissue homeostasis, emphasizing the need for therapeutic interventions targeting these cells. | However, it's important to note that while the absolute number of senescent cells might decline in advanced age, their relative impact on tissue function and inflammation can remain significant. The presence of even a small proportion of senescent cells can disrupt tissue homeostasis, emphasizing the need for therapeutic interventions targeting these cells. | ||
== Implications for Age-Related Diseases == | |||
Age-related diseases are the main causes of death and disability. These diseases include cardiovascular disease, cancer, Alzheimer's disease, diabetes, kidney failure, and osteoarthritis. They affect different organ systems and have different origins, including mutations, dysregulated homeostasis, fibrosis, and degenerative processes. | |||
[[File:Incidence Rate of Age-Related Diseases.png|thumb|Incidence Rate of Age-Related Diseases]] | |||
Despite the differences between these pathologies, they have certain universal features in terms of their incidence rate. The [[wikipedia:Incidence_(epidemiology)|incidence rate]] of a disease is defined as the number of new cases per year divided by the size of the population. The incidence rate of each age-related disease rises roughly exponentially with age (Belikov, 2019; Zenin et al., 2019). For many of the diseases, the incidence rate then drops at very old ages. Interestingly, the slope of the rising part of the incidence curve is similar for many age-related diseases, in the range of 6–8% per year (Belikov, 2019; Zenin et al., 2019) (Figure 1a) . This similarity hints at a common biological process of aging that governs the onset of these different diseases (Finch & Kirkwood, 2000; Franceschi et al., 2018; Justice et al., 2018; Kaeberlein, 2017; Kennedy et al., 2014; Kirkland, 2016; Kirkwood, 2005; Kritchevsky & Justice, 2020; Olshansky et al., 2007). It is thus of interest to develop theories for the origin of the incidence of age-related diseases, in order to detect such a common process. | |||
== Implications for Aging and Disease == | == Implications for Aging and Disease == | ||