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There are several primary methyl donors in human physiology: | There are several primary methyl donors in human physiology: | ||
{| class="wikitable" | |||
|+ | |||
!Methyl Donor | |||
!Description | |||
|- | |||
|[[S-Adenosylmethionine (SAMe)]] | |||
|Produced from methionine and ATP, SAMe is a principal methyl group donor involved in numerous methylation reactions. It’s vital for the synthesis of neurotransmitters, nucleic acids, proteins, and lipids. | |||
|- | |||
|[[Trimethylglycine (TMG)]] | |||
|Found in various foods like beets and spinach, betaine is involved in the conversion of homocysteine to methionine, donating a methyl group in the process. | |||
|- | |||
|[[Vitamin B9 (Folate)]] | |||
|Folate is central to the one-carbon metabolism cycle, where it assists in transferring one-carbon units for DNA synthesis and repair. | |||
|- | |||
|[[Vitamin B12 (Cobalamin)]] | |||
|This vitamin works closely with folate in the methionine synthase reaction, converting homocysteine back to methionine. | |||
|} | |||
# | |||
== Methyl Donors and Aging == | == Methyl Donors and Aging == |