2,851
edits
ApoE−/− mice: Difference between revisions
no edit summary
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
Apoe−/− mice, or Apolipoprotein E knockout mice, are a genetically modified mouse model widely used in biomedical research. The Apolipoprotein E (ApoE) gene is crucial for lipid metabolism, and its absence in these mice leads to the development of atherosclerosis, making them an invaluable model for studying cardiovascular diseases, lipid metabolism disorders, and neurodegenerative diseases like Alzheimer’s. | Apoe−/− mice, or Apolipoprotein E knockout mice, are a genetically modified mouse model widely used in biomedical research. The Apolipoprotein E (ApoE) gene is crucial for lipid metabolism, and its absence in these mice leads to the development of atherosclerosis, making them an invaluable model for studying cardiovascular diseases, lipid metabolism disorders, and neurodegenerative diseases like Alzheimer’s. <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875735/</ref> | ||
=== Apolipoprotein E (ApoE) Gene === | === Apolipoprotein E (ApoE) Gene === | ||
| Line 9: | Line 9: | ||
=== Alzheimer’s Disease and Apoe−/− Mice === | === Alzheimer’s Disease and Apoe−/− Mice === | ||
Beyond cardiovascular research, Apoe−/− mice are also instrumental in studying Alzheimer’s disease (AD). ApoE is implicated in the pathogenesis of AD, with the E4 isoform being a major genetic risk factor for the disease. Apoe−/− mice are used to investigate the role of ApoE in amyloid-beta deposition, one of the hallmarks of AD, and to explore new therapeutic strategies for preventing or treating Alzheimer’s disease. | Beyond cardiovascular research, Apoe−/− mice are also instrumental in studying Alzheimer’s disease (AD). ApoE is implicated in the pathogenesis of AD, with the E4 isoform being a major genetic risk factor for the disease. Apoe−/− mice are used to investigate the role of ApoE in amyloid-beta deposition, one of the hallmarks of AD, and to explore new therapeutic strategies for preventing or treating Alzheimer’s disease. | ||
== References == | |||
<references /> | |||
[[Category:Model Organism]] | [[Category:Model Organism]] | ||