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Sirtuins: Difference between revisions
→Types of Sirtuins
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Sirtuins are not a homogenous group; instead, they can be categorized into several distinct types, each with its unique functions and locations within the cell. Understanding these different sirtuin types is crucial to appreciate the diverse roles they play in cellular physiology. | Sirtuins are not a homogenous group; instead, they can be categorized into several distinct types, each with its unique functions and locations within the cell. Understanding these different sirtuin types is crucial to appreciate the diverse roles they play in cellular physiology. | ||
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!Sirtuine | |||
!Description | |||
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|SIRT1 | |||
|Found primarily in the cell nucleus, SIRT1 is involved in DNA repair, gene expression regulation, and various metabolic processes. | |||
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|SIRT2 | |||
|Predominantly found in the cytoplasm, SIRT2 regulates cell cycle progression and is associated with maintaining cell integrity. | |||
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|SIRT3, SIRT4 and SIRT5 | |||
|These sirtuins are primarily located in the mitochondria and are pivotal for maintaining mitochondrial function, energy production, and metabolic homeostasis. | |||
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|SIRT6 | |||
|Operating within the cell nucleus, SIRT6 plays a crucial role in DNA repair, genome stability, and metabolic regulation. | |||
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|SIRT7 | |||
|Also situated in the cell nucleus, SIRT7 is involved in ribosome biogenesis and RNA transcription. | |||
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=== Evolutionary Significance of Sirtuins === | === Evolutionary Significance of Sirtuins === | ||