Quercetin: Difference between revisions

* '''Absorption and Bioavailability''': Quercetin's bioavailability is notably limited due to its poor water solubility. It is usually metabolized extensively in the intestines and liver, with only a small fraction reaching systemic circulation. Various formulations and delivery systems, like quercetin phytosomes, have been developed to enhance its bioavailability.

* '''Metabolism and Elimination''': Once absorbed, quercetin undergoes extensive metabolism, primarily in the liver, involving processes like glucuronidation, sulfation, and methylation, which result in the formation of various metabolites. These metabolites are then eliminated chiefly through bile and, to a lesser extent, in urine, impacting the overall biological activity and duration of action of quercetin in the body.

* '''Mode of Action''': Quercetin exerts its effects predominantly through its antioxidant and anti-inflammatory properties. It can scavenge free radicals and reduce oxidative stress, modulate signaling pathways involved in inflammation, and inhibit the formation and release of pro-inflammatory mediators. It has also demonstrated the ability to modulate several cellular enzymes and receptors, thus influencing a variety of biological processes and potentially offering protection against a range of diseases.