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Apigenin: Difference between revisions
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[[Apigenin]] is a natural compound known as a flavone, a class of flavonoids. It’s recognized for its promising bioactive properties, notably its potential role in promoting longevity and overall health, by virtue of its influence on cellular functions and its antioxidant, anti-inflammatory, and anti-cancer properties. | [[Apigenin]] is a natural compound known as a flavone, a class of flavonoids. It’s recognized for its promising bioactive properties, notably its potential role in promoting longevity and overall health, by virtue of its influence on cellular functions and its antioxidant, anti-inflammatory, and anti-cancer properties. | ||
Apigenin is found abundantly in various plant foods, such as parsley, celery, and chamomile tea. It’s a subject of increasing research interest due to its diverse biological activities and its potential benefits in preventing and managing a range of health conditions, from metabolic disorders to age-related diseases. | Apigenin is found abundantly in various plant foods, such as parsley, celery, and chamomile tea. It’s a subject of increasing research interest due to its diverse biological activities and its potential benefits in preventing and managing a range of health conditions, from metabolic disorders to age-related diseases. | ||
Research on apigenin in the context of longevity focuses primarily on its ability to modulate several cellular pathways related to aging. Apigenin is studied for its potential to inhibit [[CD38]], an enzyme that consumes [[Nicotinamide Adenine Dinucleotide (NAD)|NAD+]], a vital coenzyme in cellular energy metabolism and repair processes. By potentially maintaining or elevating NAD+ levels, apigenin could play a role in delaying the aging process and mitigating age-related declines in cellular function. Additionally, its antioxidative and anti-inflammatory properties contribute to its role in promoting cellular health and longevity. | Research on apigenin in the context of longevity focuses primarily on its ability to modulate several cellular pathways related to aging. Apigenin is studied for its potential to inhibit [[CD38]], an enzyme that consumes [[Nicotinamide Adenine Dinucleotide (NAD)|NAD+]], a vital coenzyme in cellular energy metabolism and repair processes. <ref>Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 2013 Apr;62(4):1084-93. doi: 10.2337/db12-1139. Epub 2012 Nov 19. PMID: 23172919; PMCID: PMC3609577.</ref> By potentially maintaining or elevating NAD+ levels, apigenin could play a role in delaying the aging process and mitigating age-related declines in cellular function. Additionally, its antioxidative and anti-inflammatory properties contribute to its role in promoting cellular health and longevity. | ||
== Sources of Apigenin == | == Sources of Apigenin == | ||