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Quercetin: Difference between revisions
→Enhancing Bioavailability and Solubility
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! Formulation | ! Formulation | ||
!Alternative Names!! | !Alternative Names!! Relative Bioavailability | ||
!Total Quercetin!! Solubility in Water !! Notes | |||
|- | |- | ||
| Standard Quercetin | | Standard Quercetin | ||
| || 1 (baseline) || Very Low || Naturally occurring in various plants; serves as the baseline form of quercetin with poor solubility and bioavailability. | | || 1 (baseline) | ||
|100%|| Very Low || Naturally occurring in various plants; serves as the baseline form of quercetin with poor solubility and bioavailability. | |||
|- | |- | ||
| Quercetin Dihydrate | | Quercetin Dihydrate | ||
| || – || Moderate || Synthetic form with two water molecules associated; usually preferred for dietary supplements due to improved solubility. | | || – | ||
|100%|| Moderate || Synthetic form with two water molecules associated; usually preferred for dietary supplements due to improved solubility. | |||
|- | |- | ||
| Quercetin Phytosomes | | Quercetin Phytosomes | ||
|Quercetin-Phospholipid | |Quercetin-Phospholipid | ||
| Up to 20 times || Improved || Significantly increases oral bioavailability compared to standard quercetin. | | Up to 20 times | ||
|~40%|| Improved || Significantly increases oral bioavailability compared to standard quercetin. | |||
|- | |- | ||
| Nanoparticle Formulations | | Nanoparticle Formulations | ||
|Nanoquercetin, Quercetin Nanocapsules | |Nanoquercetin, Quercetin Nanocapsules | ||
| Several-fold increase || Variable, generally improved || Includes liposomal encapsulations; increased solubility and cellular uptake. | | Several-fold increase | ||
| || Variable, generally improved || Includes liposomal encapsulations; increased solubility and cellular uptake. | |||
|- | |- | ||
| Complexation with Cyclodextrins | | Complexation with Cyclodextrins | ||
|Quercetin-β-Cyclodextrin Complex | |Quercetin-β-Cyclodextrin Complex | ||
| Up to 10 times || Enhanced || Improves water solubility significantly, enhancing therapeutic effects. | | Up to 10 times | ||
| || Enhanced || Improves water solubility significantly, enhancing therapeutic effects. | |||
|- | |- | ||
| Co-administration with Piperine | | Co-administration with Piperine | ||
|Bioavailability Enhanced Quercetin, Piperine-Quercetin Combination | |Bioavailability Enhanced Quercetin, Piperine-Quercetin Combination | ||
| Approximately 20% || Low || Inhibits metabolism of quercetin, improving its bioavailability. | | Approximately 20% | ||
| || Low || Inhibits metabolism of quercetin, improving its bioavailability. | |||
|- | |- | ||
| Liposomal Quercetin | | Liposomal Quercetin | ||
| || Several-fold increase || Encapsulated in lipid bilayer || Liposomes enhance solubility and cellular uptake. | | || Several-fold increase | ||
| || Encapsulated in lipid bilayer || Liposomes enhance solubility and cellular uptake. | |||
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