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Quercetin: Difference between revisions

400 bytes added ,  27 September 2023
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===Quercetin Phytosome===
===Quercetin Phytosome===
Quercetin Phytosome is a formulation where quercetin is bound to phospholipids, typically derived from sunflower or soy lecithin, to enhance its bioavailability and absorption. The relevant clinical study used Quercetin Phytosome (QUERCEFIT™) consisting of quercetin and sunflower lecithin in a 1:1 weight ratio along with about a fifth part of food-grade excipients that are added to improve the physical state of the product and to standardize it to an HPLC-measured total quercetin content of about 40%.
Quercetin Phytosome is a formulation where quercetin is bound to phospholipids, typically derived from sunflower or soy lecithin, to enhance its bioavailability and absorption. The relevant clinical study used Quercetin Phytosome (QUERCEFIT™) consisting of quercetin and sunflower lecithin in a 1:1 weight ratio along with about a fifth part of food-grade excipients that are added to improve the physical state of the product and to standardize it to an HPLC-measured total quercetin content of about 40%.
[[File:Pharmacokinetic profile of quercetin.png|thumb|463x463px|Pharmacokinetic profile of quercetin in the clinical study. The plasma concentrations of quercetin obtained after single oral administration of the unformulated quercetin at 500 mg/tablet and after single oral administration of its corresponding lecithin formulation, Quercetin Phytosome, at a dose of either 500 or 250 mg are shown.]]


In the clinical study, a ~20-fold increase in bioavailability was measured compared to standard quercetin with equal doses. Given that Quercetin Phytosome contains ~40% and has a ~20 fold relative bioavailability, one can assume that the total bioavailability of standard quercetin is less than 2%.
In the clinical study, a ~20-fold increase in bioavailability was measured compared to standard quercetin with equal doses. Given that Quercetin Phytosome contains ~40% and has a ~20 fold relative bioavailability, one can assume that the total bioavailability of standard quercetin is less than 2%.
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