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Quercetin: Difference between revisions
→Formulation of Enhanced Bioavailability
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! Formulation | ! Formulation | ||
!Alternative Names!! Relative Bioavailability | !Alternative Names!! Relative Bioavailability!! Solubility in Water !! Notes | ||
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| Standard Quercetin | | Standard Quercetin | ||
| || 1 (baseline) | | || 1 (baseline) || Very Low || Naturally occurring in various plants; serves as the baseline form of quercetin with poor solubility and bioavailability. | ||
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| Quercetin Dihydrate | | Quercetin Dihydrate | ||
| || – | | || – || Moderate || Synthetic form with two water molecules associated; usually preferred for dietary supplements due to improved solubility. | ||
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| Quercetin Phytosomes | | Quercetin Phytosomes | ||
|Quercetin-Phospholipid | |Quercetin-Phospholipid | ||
| Up to 20 times | | Up to 20 times || Improved || Significantly increases oral bioavailability compared to standard quercetin. | ||
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| Nanoparticle Formulations | | Nanoparticle Formulations | ||
|Nanoquercetin, Quercetin Nanocapsules | |Nanoquercetin, Quercetin Nanocapsules | ||
| Several-fold increase | | Several-fold increase || Variable, generally improved || Includes liposomal encapsulations; increased solubility and cellular uptake. | ||
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| Complexation with Cyclodextrins | | Complexation with Cyclodextrins | ||
|Quercetin-β-Cyclodextrin Complex | |Quercetin-β-Cyclodextrin Complex | ||
| Up to 10 times | | Up to 10 times || Enhanced || Improves water solubility significantly, enhancing therapeutic effects. | ||
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| Co-administration with Piperine | | Co-administration with Piperine | ||
|Bioavailability Enhanced Quercetin, Piperine-Quercetin Combination | |Bioavailability Enhanced Quercetin, Piperine-Quercetin Combination | ||
| Approximately 20% | | Approximately 20% | ||
| Low || Inhibits metabolism of quercetin, improving its bioavailability. | | Low || Inhibits metabolism of quercetin, improving its bioavailability. | ||
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| Liposomal Quercetin | | Liposomal Quercetin | ||
| || Several-fold increase | | || Several-fold increase || Encapsulated in lipid bilayer || Liposomes enhance solubility and cellular uptake. | ||
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