Nicotinamide Mononucleotide (NMN): Difference between revisions

Nicotinamide Mononucleotide (NMN) (view source)

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 NMN and its impact on longevity are at the cutting edge of anti-aging research, with new discoveries and insights emerging regularly, deepening our understanding of the aging process and potential interventions to extend health and lifespan.
-== Taking NMN ==
-=== When to Take ===
-Our body has a natural rhythm where NAD levels fluctuate throughout the day rather than remaining constant, closely tied to our circadian rhythms. A study by Shin Imai and his team highlighted that NAD plays a crucial role in regulating our body's internal clock. The Sirt-1 gene, which is influenced by NAD, signals our body when it's time to eat or sleep.
-For those considering NMN supplementation, it's suggested to take NMN in the morning when the natural rise in NAD and [[SIRT1|Sirt-1]] activity should happen. Taking NMN e.g. at night might disrupt the NAD cycle and potentially affecting the sleep or hunger. This can be especially beneficial for frequent travelers trying to adjust to a new time zone, as a morning dose of NMN can help reset the body's internal clock and reduce jet lag.   <ref>[[2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging]]</ref>
-=== Combining NMN with Methyl Donors ===
-There's a theoretical concern regarding the consumption of NMN (nicotinamide mononucleotide) and its potential to use up methyl groups in the body. The reasoning is as follows:
-# NMN is converted into NAD+ in the body.
-# NAD+ can be broken down into nicotinamide.
-# Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which can be excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body.
-The potential concern is that excessive NMN supplementation might lead to a decrease in the body's available methyl groups, which play crucial roles in various biological processes including DNA methylation and neurotransmitter synthesis.
-For that reason, some individuals who take NMN also supplement with [[Trimethylglycine (TMG)]], a [[Methyl Donors|methyl donor]], to ensure that they are not depleting their body's methyl groups. However, this is a precautionary measure and not necessarily based on concrete evidence. [[NOVOS]] use B vitamins and phosphatidylcholine as methyl donors in their product to avoid the side effects of TMG and because they think that TMG is already too deep into the methylation pathways, not allowing the body to choose the amount of methylation for itself. <ref>https://novoslabs.com/frequently-asked-questions/nmn-nicotinamide-mononucleotide/do-you-need-to-combine-nmn-with-tmg-trimethylglycine/</ref>
-However, there are a few important points to consider:
-# '''No clear evidence yet''': While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It's a theoretical concern, and it would require substantial NMN consumption to have a significant impact.
-# '''Compensatory mechanisms''': The human body has various feedback mechanisms. If methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide.
-# '''Methyl donors in diet''': Many people consume methyl donors like choline, betaine, and folate in their diets. These can help replenish methyl groups.
-=== Effects ===
-* Human studies have shown that show that taking 1000 mg over 10 days raises your NAD levels about two-fold. But you can go as high as 2000 mg and triple the amount.
 == NMN in food ==
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+== Taking NMN ==
+=== When to Take ===
+Our body has a natural rhythm where NAD levels fluctuate throughout the day rather than remaining constant, closely tied to our circadian rhythms. A study by Shin Imai and his team highlighted that NAD plays a crucial role in regulating our body's internal clock. The Sirt-1 gene, which is influenced by NAD, signals our body when it's time to eat or sleep.
+For those considering NMN supplementation, it's suggested to take NMN in the morning when the natural rise in NAD and [[SIRT1|Sirt-1]] activity should happen. Taking NMN e.g. at night might disrupt the NAD cycle and potentially affecting the sleep or hunger. This can be especially beneficial for frequent travelers trying to adjust to a new time zone, as a morning dose of NMN can help reset the body's internal clock and reduce jet lag.   <ref>[[2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging]]</ref>
+=== Combining NMN with Methyl Donors ===
+There's a theoretical concern regarding the consumption of NMN (nicotinamide mononucleotide) and its potential to use up methyl groups in the body. The reasoning is as follows:
+# NMN is converted into NAD+ in the body.
+# NAD+ can be broken down into nicotinamide.
+# Nicotinamide is then methylated by the liver to form N1-methylnicotinamide, which can be excreted in the urine. This methylation process consumes a methyl group from [[S-adenosylmethionine (SAMe)]], the primary methyl donor in the body.
+The potential concern is that excessive NMN supplementation might lead to a decrease in the body's available methyl groups, which play crucial roles in various biological processes including DNA methylation and neurotransmitter synthesis.
+For that reason, some individuals who take NMN also supplement with [[Trimethylglycine (TMG)]], a [[Methyl Donors|methyl donor]], to ensure that they are not depleting their body's methyl groups. However, this is a precautionary measure and not necessarily based on concrete evidence. [[NOVOS]] use B vitamins and phosphatidylcholine as methyl donors in their product to avoid the side effects of TMG and because they think that TMG is already too deep into the methylation pathways, not allowing the body to choose the amount of methylation for itself. <ref>https://novoslabs.com/frequently-asked-questions/nmn-nicotinamide-mononucleotide/do-you-need-to-combine-nmn-with-tmg-trimethylglycine/</ref>
+However, there are a few important points to consider:
+# '''No clear evidence yet''': While the pathway is known, the actual significance of NMN supplementation on global methyl group status is not well-established in humans. It's a theoretical concern, and it would require substantial NMN consumption to have a significant impact.
+# '''Compensatory mechanisms''': The human body has various feedback mechanisms. If methyl groups were being depleted at a concerning rate, the body would likely slow down the conversion of NMN to NAD+ or the methylation of nicotinamide.
+# '''Methyl donors in diet''': Many people consume methyl donors like choline, betaine, and folate in their diets. These can help replenish methyl groups.
+=== Effects ===
+* Human studies have shown that show that taking 1000 mg over 10 days raises your NAD levels about two-fold. But you can go as high as 2000 mg and triple the amount.
 == Clinical Trials ==