Nicotinamide Mononucleotide (NMN): Difference between revisions

* '''Limited Human Studies:''' Most of the studies on NMN have been conducted in animal models, and there is limited data on its effects in humans. Therefore, the safety and efficacy of NMN supplementation in humans are not fully understood, and caution is advised until more research is conducted.

* '''Potential Interaction with Medications''': The interaction of NMN with various medications is not well studied, and there could be potential risks when combined with certain drugs. Individuals on medication should consult with a healthcare professional before considering NMN supplementation.

* '''Theoretical Concerns''': There are theoretical concerns regarding NMN’s potential to deplete methyl groups in the body, which could impact various biological processes, including DNA methylation and neurotransmitter synthesis. While this is a theoretical concern and not substantiated by concrete evidence, it is important to consider when evaluating the potential risks of NMN supplementation.{{Citation needed}}

* '''Over-Supplementation Risks''': Excessive supplementation of NMN may lead to unknown side effects due to the lack of long-term human studies. Over-supplementation might also disrupt the natural balance of NAD+ and its related compounds in the body, potentially leading to unforeseen consequences.

* '''Purity and Quality Concerns''': The purity and quality of NMN supplements can vary, and impurities or contaminants in the supplements pose additional risks. It is essential to choose high-quality, reputable brands and sources for NMN supplements to minimize risks associated with impurities and contaminants.