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Quercetin: Difference between revisions
→Quercetin LipoMicel
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=== Quercetin LipoMicel === | === Quercetin LipoMicel === | ||
'''Quercetin LipoMicel''' is a novel formulation from Natural Factors designed to enhance the bioavailability of quercetin. LipoMicel encapsulates quercetin molecules within micelles, tiny spherical structures formed from natural, non-ionic surfactants. These micelles facilitate the solubilization of quercetin, allowing it to be more readily absorbed in the gastrointestinal tract. In a study sponsored by Natural Factors, the bioavailability of Standard Quercetin, Quercetin Phytosome and Quercetin LipoMicel was compared. Thereby, Quercetin Phytosome had a slightly higher relative bioavailability (AUC) than for Quercetin LipoMicel, but longer steady state levels of quercetin were provided by LipoMicel. | '''Quercetin LipoMicel''' is a novel formulation from Natural Factors designed to enhance the bioavailability of quercetin. LipoMicel encapsulates quercetin molecules within micelles, tiny spherical structures formed from natural, non-ionic surfactants. These micelles facilitate the solubilization of quercetin, allowing it to be more readily absorbed in the gastrointestinal tract. In a study sponsored by Natural Factors, the bioavailability of Standard Quercetin, Quercetin Phytosome and Quercetin LipoMicel was compared. Thereby, Quercetin Phytosome had a slightly higher relative bioavailability (AUC) than for Quercetin LipoMicel, but longer steady state levels of quercetin were provided by LipoMicel. <ref name=":1">https://jnhpresearch.com/index.php/jnhpr/article/view/17/24</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
|+[[Pharmacokinetic]] parameters | |+[[Pharmacokinetic]] parameters <ref name=":1" /> | ||
! | ! | ||
!Quercetin | !Quercetin 500mg | ||
!Quercetin | !Quercetin LipoMicel 500mg | ||
!Quercetin Phytosome | !Quercetin Phytosome 500mg | ||
|- | |- | ||
|[[AUClast|AUC<sub> | |[[AUClast|AUC<sub>0-24</sub>]] (ng h/ml) | ||
| | | 172.87 ± 12.21 | ||
| | | 1477.27 ± 25.57 | ||
| | | 1536.00 ± 115.66 | ||
|- | |- | ||
| colspan="1" rowspan="1" |[[Cmax|C<sub>max</sub>]] (ng/ml) | | colspan="1" rowspan="1" |[[Cmax|C<sub>max</sub>]] (ng/ml) | ||
| | | 19.77 ± 27.29 | ||
| | | 182.85 ± 106.64 | ||
| | | 150.27 ± 61.43 | ||
|- | |- | ||
| colspan="1" rowspan="1" |[[Time to Maximum Concentration (Tmax)|T<sub>max</sub>]] ( | | colspan="1" rowspan="1" |[[Time to Maximum Concentration (Tmax)|T<sub>max</sub>]] (hours) | ||
| | | 2 ± 0.15 | ||
| | | 0.5 ± 0.02 | ||
| | | 1 ± 0.30 | ||
|- | |- | ||
| colspan="1" rowspan="1" |''t''<sub>1/2</sub> ( | | colspan="1" rowspan="1" |''t''<sub>1/2</sub> (hours) | ||
| | | 11.66 ± 0.55 | ||
| | | 8.29 ± 0.49 | ||
| | | 6.02 ± 0.52 | ||
|} | |} | ||