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Quercetin: Difference between revisions

912 bytes added ,  5 October 2023
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In a study sponsored by Natural Factors, the bioavailability of Standard Quercetin, Quercetin Phytosome and Quercetin LipoMicel was evaluated. The results indicated that Quercetin LipoMicel had a relative bioavailability to Standard Quercetin of 8.5, while Quercetin Phytosome exhibited a slightly higher value of 8.9. Notably, LipoMicel maintained more consistent levels of quercetin in the system over a 24-hour period. <ref name=":1">https://jnhpresearch.com/index.php/jnhpr/article/view/17/24</ref>
In a study sponsored by Natural Factors, the bioavailability of Standard Quercetin, Quercetin Phytosome and Quercetin LipoMicel was evaluated. The results indicated that Quercetin LipoMicel had a relative bioavailability to Standard Quercetin of 8.5, while Quercetin Phytosome exhibited a slightly higher value of 8.9. Notably, LipoMicel maintained more consistent levels of quercetin in the system over a 24-hour period. <ref name=":1">https://jnhpresearch.com/index.php/jnhpr/article/view/17/24</ref>
In a second study, the blood concentrations of quercetin in healthy participants after the administration of standard quercetin and LipeMice quercetin was evaluated with over 72 hours and 4 doses in total. Within the first 24 hours, LipeMice (500mg) had a significantly 7-fold increased blood concentrations of quercetin compared to standard quercetin (500 mg). LipeMice administered at a double dose (1000 mg) achieved 15-fold higher absorption, LipeMice tested at half a dose of standard quercetin increased concentration by approx. 3-fold. Quercetin blood concentrations were attained over 72 hours. <ref name=":2">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435304/</ref>


{| class="wikitable"
{| class="wikitable"
|+[[Pharmacokinetic]] parameters <ref name=":1" />
|+[[Pharmacokinetic]] parameters
!
!
!Quercetin 500mg
! colspan="3" |Study 1 <ref name=":1" />
!Quercetin LipoMicel 500mg
! colspan="4" |Study 2 <ref name=":2" />
!Quercetin Phytosome 500mg
|-
!
!Quercetin
500mg
!Quercetin LipoMicel
500mg
!Quercetin Phytosome
500mg
!Quercetin
500mg
!Quercetin LipoMicel
250mg
!Quercetin LipoMicel
500mg
!Quercetin LipoMicel
1000mg
|-
|-
|[[AUClast|AUC<sub>0-24</sub>]] (ng h/ml)
|[[AUClast|AUC<sub>0-24</sub>]] (ng h/ml)
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| 1477.27 ± 25.57
| 1477.27 ± 25.57
| 1536.00 ± 115.66
| 1536.00 ± 115.66
|77.3 (SD=6.1)
|
|
|
|-
|-
| colspan="1" rowspan="1" |[[Cmax|C<sub>max</sub>]] (ng/ml)
| colspan="1" rowspan="1" |[[Cmax|C<sub>max</sub>]] (ng/ml)
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| 182.85 ± 106.64
| 182.85 ± 106.64
| 150.27 ± 61.43
| 150.27 ± 61.43
|197.0 (SD=8.0
|
|
|
|-
|-
| colspan="1" rowspan="1" |[[Time to Maximum Concentration (Tmax)|T<sub>max</sub>]] (hours)
| colspan="1" rowspan="1" |[[Time to Maximum Concentration (Tmax)|T<sub>max</sub>]] (hours)
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| 0.5 ± 0.02
| 0.5 ± 0.02
| 1 ± 0.30
| 1 ± 0.30
|
|
|
|
|-
|-
| colspan="1" rowspan="1" |[[Elimination Half-Life|''t''<sub>1/2</sub>]] (hours)
| colspan="1" rowspan="1" |[[Elimination Half-Life|''t''<sub>1/2</sub>]] (hours)
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| 8.29 ± 0.49
| 8.29 ± 0.49
| 6.02 ± 0.52
| 6.02 ± 0.52
|
|
|
|
|}
|}


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