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Quercetin: Difference between revisions
→Poor Bioavailability of Standard Quercetin
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Once absorbed, quercetin undergoes extensive first-pass metabolism in the liver and intestines, where it is converted into various metabolites through glucuronidation, sulfation, and methylation. The extensive metabolism significantly reduces the concentrations of free quercetin in the plasma, limiting its bioavailability. The metabolites, however, may retain some biological activity and contribute to the overall effects of quercetin in the body. | Once absorbed, quercetin undergoes extensive first-pass metabolism in the liver and intestines, where it is converted into various metabolites through glucuronidation, sulfation, and methylation. The extensive metabolism significantly reduces the concentrations of free quercetin in the plasma, limiting its bioavailability. The metabolites, however, may retain some biological activity and contribute to the overall effects of quercetin in the body. | ||
It is suggested that individuals with poor vitamin C status might absorb quercetin better than those with adequate vitamin C levels. This could indicate a compensatory mechanism where the body might try to absorb more of certain beneficial compounds, like quercetin, in the absence of others, like vitamin C. However, the exact mechanisms or reasons behind this would need to be further explored. <ref>https://pubmed.ncbi.nlm.nih.gov/25280405/</ref> | |||
===Formulation of Enhanced Bioavailability=== | ===Formulation of Enhanced Bioavailability=== | ||