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Resveratrol: Difference between revisions

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One of the mechanisms by which resveratrol is thought to impact aging is by mimicking the effects of caloric restriction, a well-known intervention for extending lifespan. It activates sirtuins (in particularly SIRT1), proteins associated with longevity, and influences metabolic processes related to aging.
One of the mechanisms by which resveratrol is thought to impact aging is by mimicking the effects of caloric restriction, a well-known intervention for extending lifespan. It activates sirtuins (in particularly SIRT1), proteins associated with longevity, and influences metabolic processes related to aging.


A recent study <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346321/</ref> in a [[Randomized Controlled Trial|randomized trial]] involving adults aged 55 to 65 compared the effects of resveratrol supplementation to a caloric-restricted diet. Both interventions raised circulating SIRT1 levels and reduced plasma noradrenaline, suggesting cardiovascular benefits. However, the study found differences between the groups in vascular reactions. Specifically, improvements in nitrate-mediated vasodilation (NMD) were seen only with caloric restriction, not with resveratrol. Additionally, SIRT1 was linked to enhanced flow-mediated vasodilation (FMD) in men but not in women. This suggests that while resveratrol mirrors some benefits of caloric restriction, it doesn't capture all, especially regarding vascular effects.
A recent study <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346321/</ref> in a [[Randomized Controlled Trial|randomized trial]] involving adults aged 55 to 65 compared the effects of resveratrol supplementation to a caloric-restricted diet. Both interventions raised circulating SIRT1 levels and reduced plasma noradrenaline, suggesting cardiovascular benefits. However, the study found differences between the groups in vascular reactions. Specifically, improvements in [[Nitrate-Mediated Vasodilation (NMD)|nitrate-mediated vasodilation (NMD)]] were seen only with caloric restriction, not with resveratrol. Additionally, SIRT1 was linked to enhanced flow-mediated vasodilation (FMD) in men but not in women. This suggests that while resveratrol mirrors some benefits of caloric restriction, it doesn't capture all, especially regarding vascular effects.


==Forms of Resveratrol ==
==Forms of Resveratrol ==
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