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Resveratrol: Difference between revisions
→Caloric Restriction Mimetic
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One of the mechanisms by which resveratrol is thought to impact aging is by mimicking the effects of caloric restriction, a well-known intervention for extending lifespan. It activates sirtuins (in particularly SIRT1), proteins associated with longevity, and influences metabolic processes related to aging. | One of the mechanisms by which resveratrol is thought to impact aging is by mimicking the effects of caloric restriction, a well-known intervention for extending lifespan. It activates sirtuins (in particularly SIRT1), proteins associated with longevity, and influences metabolic processes related to aging. | ||
A recent study <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346321/</ref> in a [[Randomized Controlled Trial|randomized trial]] involving adults aged 55 to 65 compared the effects of resveratrol supplementation to a caloric-restricted diet. Both interventions raised circulating SIRT1 levels and reduced plasma noradrenaline, suggesting cardiovascular benefits. However, the study found differences between the groups in vascular reactions. Specifically, improvements in nitrate-mediated vasodilation (NMD) were seen only with caloric restriction, not with resveratrol. Additionally, SIRT1 was linked to enhanced flow-mediated vasodilation (FMD) in men but not in women. This suggests that while resveratrol mirrors some benefits of caloric restriction, it doesn't capture all, especially regarding vascular effects. | A recent study <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346321/</ref> in a [[Randomized Controlled Trial|randomized trial]] involving adults aged 55 to 65 compared the effects of resveratrol supplementation to a caloric-restricted diet. Both interventions raised circulating SIRT1 levels and reduced plasma noradrenaline, suggesting cardiovascular benefits. However, the study found differences between the groups in vascular reactions. Specifically, improvements in [[Nitrate-Mediated Vasodilation (NMD)|nitrate-mediated vasodilation (NMD)]] were seen only with caloric restriction, not with resveratrol. Additionally, SIRT1 was linked to enhanced flow-mediated vasodilation (FMD) in men but not in women. This suggests that while resveratrol mirrors some benefits of caloric restriction, it doesn't capture all, especially regarding vascular effects. | ||
==Forms of Resveratrol == | ==Forms of Resveratrol == | ||