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Mice (Mus Musculus): Difference between revisions
→Differences Between Human and Mouse Model
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{| class="wikitable" | {| class="wikitable" | ||
!Feature | !Feature | ||
!Mouse Model | |||
!Human | !Human | ||
!Difference | !Difference | ||
|- | |- | ||
|Lifespan | |Lifespan | ||
|~2-3 years | |||
|~80 years (average) | |~80 years (average) | ||
|~40x | |~40x | ||
|- | |- | ||
|Reproductive Age Start | |Reproductive Age Start | ||
|~6-8 weeks | |||
|~12-15 years | |~12-15 years | ||
|~100x | |~100x | ||
|- | |- | ||
|Growth Rate | |Growth Rate | ||
|2-3 months to maturity | |||
|18-25 years to reach full adult size | |18-25 years to reach full adult size | ||
|~90x to ~100x | |~90x to ~100x | ||
|- | |- | ||
|Genome | |Genome | ||
|~20,000-25,000 protein-coding genes | |~20,000-25,000 protein-coding genes | ||
|~20,000-25,000 protein-coding genes | |~20,000-25,000 protein-coding genes | ||
|differences in some gene families and pathways | |differences in some gene families and pathways | ||
|- | |- | ||
|Genome Size | |Genome Size | ||
|~2.7 billion base pairs | |||
|~3.2 billion base pairs | |~3.2 billion base pairs | ||
| | | | ||
|- | |- | ||
|Number of Chromosomes | |Number of Chromosomes | ||
|40 (20 pairs) | |||
|46 (23 pairs) | |46 (23 pairs) | ||
| | | | ||
|- | |- | ||
|Heart Rate | |Heart Rate | ||
|~500-700 beats/minute | |||
|~60-100 beats/minute | |~60-100 beats/minute | ||
|~8x | |~8x | ||
|- | |- | ||
|Metabolic Rate | |Metabolic Rate | ||
|Faster | |||
|Slower | |Slower | ||
|Variable (often >10x) | |Variable (often >10x) | ||
|- | |- | ||
|Bone Density Decline | |Bone Density Decline | ||
|Begins around 1 year | |||
|Begins in late 20s | |Begins in late 20s | ||
|~25x | |~25x | ||
|- | |- | ||
|Body Weight | |Body Weight | ||
|20-40 g (female) & 25-45 g (male) | |||
|Average 62 kg (female) & 77 kg (male) | |Average 62 kg (female) & 77 kg (male) | ||
|~2000x (average) | |~2000x (average) | ||
|- | |- | ||
|Brain Size | |Brain Size | ||
|~0.4 cm³ | |||
|~1400 cm³ | |~1400 cm³ | ||
|~3500x | |~3500x | ||
|- | |- | ||
|Blood Volume | |Blood Volume | ||
|~2 ml | |||
|~5 liters | |~5 liters | ||
|~2500x | |~2500x | ||
|- | |- | ||
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|- | |- | ||
|Diet | |Diet | ||
|Omnivorous, often fed controlled diets in labs | |||
|Omnivorous, varied diet | |Omnivorous, varied diet | ||
| | | | ||
|- | |- | ||
|Telomere Length | |Telomere Length | ||
|Relatively longer in many cells | |||
|Shorter in somatic cells | |Shorter in somatic cells | ||
| | | | ||
|- | |- | ||
|Reproductive Cycle | |Reproductive Cycle | ||
|4-5 days (Estrous cycle) | |||
|~28 days (Menstrual cycle) | |~28 days (Menstrual cycle) | ||
|~6x | |~6x | ||
|- | |- | ||
|Pregnancy Duration | |Pregnancy Duration | ||
|~19-21 days | |||
|~280 days | |~280 days | ||
|~14x | |~14x | ||
|- | |- | ||
|Immune System | |Immune System | ||
|Faster initial response, less memory-driven | |||
|Slower response, memory-driven | |Slower response, memory-driven | ||
| | | | ||
|- | |- | ||
|Drug Metabolism | |Drug Metabolism | ||
|Faster drug metabolism due to differences in liver enzymes | |||
|Slower drug metabolism | |Slower drug metabolism | ||
| | | | ||
|- | |- | ||
|Blood Cell Lifespan | |Blood Cell Lifespan | ||
|Red cells: ~40 days | |||
|Red cells: ~120 days | |Red cells: ~120 days | ||
|~3x | |~3x | ||
|- | |- | ||
|[[Allometric Scaling]] Correction Factor | |[[Allometric Scaling]] Correction Factor | ||
|3 | |||
|37 | |37 | ||
|~12x | |||
|~ | |||
|} | |} | ||