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Mice (Mus Musculus): Difference between revisions
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# '''Rich Data Sets''': Due to the extensive use of mice in research, there's a wealth of pre-existing data available. This enables researchers to compare and contrast findings from longevity studies with data from other domains. | # '''Rich Data Sets''': Due to the extensive use of mice in research, there's a wealth of pre-existing data available. This enables researchers to compare and contrast findings from longevity studies with data from other domains. | ||
# '''Ethical Considerations''': While all animal research has ethical considerations, the use of shorter-lived organisms like mice often presents fewer ethical complexities than the use of longer-lived animals, especially primates. | # '''Ethical Considerations''': While all animal research has ethical considerations, the use of shorter-lived organisms like mice often presents fewer ethical complexities than the use of longer-lived animals, especially primates. | ||
== Mouse Strains Relevant for Longevity Research == | |||
{| class="wikitable" | |||
! Strain Name !! Description !! Key Traits !! Use in Longevity Research | |||
|- | |||
| C57BL/6 || Most commonly used inbred strain || High susceptibility to diet-induced obesity || Often used as a reference strain in aging studies | |||
|- | |||
| Ames Dwarf || Mutant strain with deficiency in growth hormone, prolactin, and thyroid-stimulating hormone || Extended lifespan; reduced tumor incidence || Key model in studying hormonal effects on aging | |||
|- | |||
| Snell Dwarf || Similar to Ames Dwarf with pituitary deficiencies || Extended lifespan; improved insulin sensitivity || Used to study hormonal regulation and aging | |||
|- | |||
| SAM (Senescence-Accelerated Mouse) || Group of related strains with accelerated aging || Varies by substrain (e.g., SAMP8 shows early cognitive decline) || Widely used in aging research to study rapid aging effects | |||
|- | |||
| ApoE−/− (Apolipoprotein E-deficient) || Mutant strain deficient in ApoE protein || Prone to cardiovascular diseases; develops atherosclerosis || Widely used in cardiovascular research, providing insights into age-related cardiovascular diseases | |||
|- | |||
| C3H || Inbred strain with a propensity for certain tumors || Prone to mammary tumors; used in cancer research || Relevant in longevity research, especially in studies linking aging and cancer | |||
|- | |||
| B6C3F1 || Hybrid strain derived from C57BL/6 and C3H || High tumor incidence in old age || Used in carcinogenicity and aging studies | |||
|- | |||
| DBA/2 || Inbred strain known for early age-related hearing loss || High bone density; resistant to diet-induced obesity || Used in sensory aging studies, particularly hearing | |||
|- | |||
| BALB/c || Inbred strain with known susceptibility to certain cancers || High levels of anxiety-like behavior || Used in cancer and aging studies | |||
|- | |||
| ICR (Institute of Cancer Research) || Outbred strain || Good reproductive performance; used as general multipurpose strain || Often used as a control strain in various research, including aging | |||
|} | |||
== Differences Between Human and Laboratory Mice == | == Differences Between Human and Laboratory Mice == | ||