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NADase: Difference between revisions
→Known NADase Enzymes
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|'''[[PARP2]]'''||PARP2, similar to PARP1, participates in DNA repair and can modify proteins through ADP-ribosylation. It also plays a role in maintaining genomic stability.||DNA repair, genomic stability, ADP-ribosylation of proteins.||Found in the nucleus, expressed in various cell types.||Influences aging-related processes, especially in DNA maintenance and repair.||Cancer, certain genetic disorders | |'''[[PARP2]]'''||PARP2, similar to PARP1, participates in DNA repair and can modify proteins through ADP-ribosylation. It also plays a role in maintaining genomic stability.||DNA repair, genomic stability, ADP-ribosylation of proteins.||Found in the nucleus, expressed in various cell types.||Influences aging-related processes, especially in DNA maintenance and repair.||Cancer, certain genetic disorders | ||
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|'''[[Sirtuins]]'''||Sirtuins, a family of NAD+-dependent deacetylases, are involved in various cellular processes like aging, gene expression regulation, and stress resistance. Some also have ADP-ribosyltransferase activity.||Regulation of gene expression, DNA repair, metabolism, stress resistance.||Widely expressed in various tissues; different sirtuins have specific distributions.||Play a critical role in aging and longevity, influencing various age-related cellular processes.||Aging-related diseases, metabolic disorders, neurodegenerative diseases | |||
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