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NADase: Difference between revisions
→Known NADase Enzymes
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|'''[[SARM1]]'''||SARM1 (Sterile Alpha and TIR Motif Containing 1) is predominantly known for its role in programmed axon degeneration and has implications in neurodegenerative conditions.||Induces axonal degeneration after injury, involved in innate immune response.||Predominantly expressed in the nervous system.||Its role in axon degeneration has implications in aging-related neurodegenerative conditions.||Neurodegenerative diseases | |'''[[SARM1]]'''||SARM1 (Sterile Alpha and TIR Motif Containing 1) is predominantly known for its role in programmed axon degeneration and has implications in neurodegenerative conditions.||Induces axonal degeneration after injury, involved in innate immune response.||Predominantly expressed in the nervous system.||Its role in axon degeneration has implications in aging-related neurodegenerative conditions.||Neurodegenerative diseases | ||
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|'''[[PARP1]]'''||PARP1 (Poly ADP-Ribose Polymerase 1) is involved in DNA repair and cell death. It uses NAD+ to add ADP-ribose units to proteins.||DNA repair, modification of nuclear proteins, cell death.||Expressed in the nucleus of cells, widespread in various tissues.||Altered PARP1 activity can influence aging processes, particularly in DNA repair mechanisms.||Cancer, neurodegenerative diseases, inflammatory diseases | |||
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|'''[[PARP2]]'''||PARP2, similar to PARP1, participates in DNA repair and can modify proteins through ADP-ribosylation. It also plays a role in maintaining genomic stability.||DNA repair, genomic stability, ADP-ribosylation of proteins.||Found in the nucleus, expressed in various cell types.||Influences aging-related processes, especially in DNA maintenance and repair.||Cancer, certain genetic disorders | |||
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