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Loss of Proteostasis: Difference between revisions
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[[File:Loss of Proteostasis.png|thumb]] | [[File:Loss of Proteostasis.png|thumb|Endogenous and exogenous stress causes the unfolding of proteins (or impairs proper folding during protein synthesis). Unfolded proteins are usually refolded by heat-shock proteins (HSP) or targeted to destruction by the ubiquitin-proteasome or lysosomal (autophagic) pathways. The autophagic pathways include recognition of unfolded proteins by the chaperone Hsc70 and their subsequent import into lysosomes (chaperone-mediated autophagy) or sequestration of damaged proteins and organelles in autophagosomes that later fuse with lysosomes (macroautophagy). Failure to refold or degrade unfolded proteins can lead to their accumulation and aggregation, resulting in proteotoxic effects.{{pmid|23746838}}]] | ||
'''Loss of Proteostasis''' is one of the primary hallmarks of aging, signifying the decline in the cell's ability to regulate protein balance. Proteostasis encompasses all aspects of protein metabolism, including the synthesis, folding, trafficking, and degradation of proteins. Efficient proteostasis is vital for maintaining cellular function and homeostasis, as proteins are integral components of all cellular processes. However, as organisms age, the proteostasis network becomes less efficient, leading to the accumulation of damaged and misfolded proteins, which can form toxic aggregates and disrupt cellular functions. | '''Loss of Proteostasis''' is one of the primary hallmarks of aging, signifying the decline in the cell's ability to regulate protein balance. Proteostasis encompasses all aspects of protein metabolism, including the synthesis, folding, trafficking, and degradation of proteins. Efficient proteostasis is vital for maintaining cellular function and homeostasis, as proteins are integral components of all cellular processes. However, as organisms age, the proteostasis network becomes less efficient, leading to the accumulation of damaged and misfolded proteins, which can form toxic aggregates and disrupt cellular functions. | ||
==The Proteostasis Network== | ==The Proteostasis Network== | ||