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Resveratrol: Difference between revisions
→Formulations and Bioavailability
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=== Conclusion === | === Conclusion === | ||
While the research on resveratrol and aging is promising, it is crucial to approach it with a balanced perspective. Ongoing studies and clinical trials are essential to validate its efficacy and understand its role in human health and longevity better. | While the research on resveratrol and aging is promising, it is crucial to approach it with a balanced perspective. Ongoing studies and clinical trials are essential to validate its efficacy and understand its role in human health and longevity better. | ||
== Forms of Resveratrol == | == Forms of Resveratrol == | ||
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=== Trans-Resveratrol === | === Trans-Resveratrol === | ||
Trans-resveratrol unfortunately suffers from '''poor bioavailability''' and '''water solubility'''. Its solubility in water is less than 0.05 mg/ml. Studies have indicated varying plasma concentrations post-consumption: <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref> | |||
* A 25 mg intake of resveratrol resulted in plasma concentrations below 10 ng/ml. | |||
* A significantly larger dose of 5000 mg led to plasma concentrations of 500 ng/ml. | |||
* Consuming 500 mg of resveratrol in tablet form produced plasma concentrations of approximately 70 ng/ml. | |||
After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. | |||
=== Micronized Resveratrol === | === Micronized Resveratrol === | ||