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edits
Resveratrol: Difference between revisions
→Trans-Resveratrol
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After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. | After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine. | ||
{| class="wikitable" | |||
|'''Number of Participants, Characteristics, Study Type''' | |||
|'''Dose (mg/day)''' | |||
|'''Days''' | |||
|'''Administration''' | |||
|'''Peak Plasma Concentration (ng/mL)''' | |||
|- | |||
|6, low BMI | |||
| rowspan="2" |2125 | |||
| rowspan="2" |11 | |||
| rowspan="2" |Tablet and drink | |||
|903.0 | |||
|- | |||
|6, high BMI | |||
|245.0 | |||
|- | |||
| rowspan="4" |35, healthy males, cross-over study | |||
| rowspan="4" |800 | |||
| rowspan="4" |5 | |||
|Capsule | |||
|0.56 | |||
|- | |||
|Dairy drink | |||
|0.61 | |||
|- | |||
|Soy drink | |||
|0.58 | |||
|- | |||
|Protein-free drink | |||
|0.70 | |||
|- | |||
|7, healthy | |||
|500 | |||
|28 | |||
|Capsule with Piperine | |||
|2967.25 | |||
|- | |||
| rowspan="4" |40, healthy, repeated sequential dosing | |||
|500 | |||
| rowspan="4" |29 | |||
| rowspan="4" |Caplet | |||
|43.8 | |||
|- | |||
|1000 | |||
|141 | |||
|- | |||
|2500 | |||
|331 | |||
|- | |||
|5000 | |||
|967 | |||
|- | |||
|6, patients with hepatic metastases, randomized double-blind clinical trial | |||
|5000 | |||
|14 | |||
|Micronized resveratrol mixed in liquid | |||
|1942 | |||
|- | |||
|8, healthy subjects | |||
|2000 | |||
|7 | |||
|Capsule | |||
|1274 | |||
|- | |||
| rowspan="3" |19, overweight or obese, randomized, double-blind, placebo-controlled, crossover intervention | |||
|30 | |||
| rowspan="3" |6 | |||
| rowspan="3" |Capsule | |||
|181.31 | |||
|- | |||
|90 | |||
|532.00 | |||
|- | |||
|270 | |||
|1232.16 | |||
|} | |||
=== Micronized Resveratrol === | === Micronized Resveratrol === | ||