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Resveratrol: Difference between revisions

1,114 bytes added ,  7 October 2023
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=== Conclusion ===
=== Conclusion ===
While the research on resveratrol and aging is promising, it is crucial to approach it with a balanced perspective. Ongoing studies and clinical trials are essential to validate its efficacy and understand its role in human health and longevity better.
While the research on resveratrol and aging is promising, it is crucial to approach it with a balanced perspective. Ongoing studies and clinical trials are essential to validate its efficacy and understand its role in human health and longevity better.


== Forms of Resveratrol ==
== Forms of Resveratrol ==
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=== Trans-Resveratrol ===
=== Trans-Resveratrol ===
Trans-resveratrol unfortunately suffers from '''poor bioavailability''' and '''water solubility'''. Its solubility in water is less than 0.05 mg/ml. Studies have indicated varying plasma concentrations post-consumption: <ref>https://www.researchgate.net/publication/331424725_Health_benefits_of_resveratrol_administration</ref>
* A 25 mg intake of resveratrol resulted in plasma concentrations below 10 ng/ml.
* A significantly larger dose of 5000 mg led to plasma concentrations of 500 ng/ml.
* Consuming 500 mg of resveratrol in tablet form produced plasma concentrations of approximately 70 ng/ml.
After consumption, 77-80% of resveratrol gets absorbed into the bloodstream through active transport via the intestinal epithelial cells. Once in the bloodstream, it associates with albumin and lipoproteins. Despite its efficient absorption, resveratrol possesses a short half-life of around 1.5 hours. This is attributed to its rapid absorption in the intestine and subsequent degradation in the liver. A significant amount of ingested resveratrol, approximately 49–61%, is eventually excreted through urine.


=== Micronized Resveratrol ===
=== Micronized Resveratrol ===
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