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| ==In grains, the [[wikipedia:Endosperm|endosperm]] contains most of the spermidine. One of the best known grain dietary sources is [[wikipedia:Wheat_germ|wheat germ]], containing as much as 243 mg/kg.==
| | ==Spermidine and Longevity== |
| ==Dietary Sources==
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| Good dietary sources of spermidine are aged cheese, mushrooms, soy products, legumes, corn, and whole grains.<ref name="Ali2011">{{cite journal | doi = 10.3402/fnr.v55i0.5572 | title = Polyamines in foods: development of a food database | year = 2011 | last1 = Ali | first1 = Mohamed Atiya | last2 = Poortvliet | first2 = Eric | last3 = Strömberg | first3 = Roger | last4 = Yngve | first4 = Agneta | journal = Food Nutr Res. | volume = 55 | pages = 5572 | pmid = 21249159 | pmc=3022763}}</ref> Spermidine is plentiful in a Mediterranean diet.<ref name="pmid29371440" />
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| For comparison: The spermidine content in human seminal plasma varies between approx. 15 and 50 mg/L (mean 31 mg/L).<ref>{{citation|editor-surname1= Ciba-Geigy|periodical=Wissenschaftliche Tabellen Geigy|title=Sperma|edition=8|volume=Teilband Körperflüssigkeiten|publisher=CIBA-GEIGY Limited|location=Basel|at=pp. 181-189|date=1977|language=de
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| }}</ref>
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| {| class="wikitable sortable"
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| ! Food !! data-sort-type="number"|Spermidine<br />mg/kg !! notes & refs
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| |Wheat germ
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| |243
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| |<ref name=":0">{{cite web|url=http://www.oryza.co.jp/html/english/pdf/polyamine_vol.2.pdf|title=Brochure on Polyamines, rev. 2|publisher=Oryza Oil & Fat Chemocial Co., Ltd.|location=Japan|date=2011-12-26|access-date=2013-11-06}}</ref>
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| | Soybean, dried || 207 || Japanese <ref name=Ali2011/>
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| | Cheddar, 1yr old || 199 || <ref name="Ali2011" />
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| | Soybean, dried || 128 || German <ref name="Ali2011" />
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| | Mushroom || 89 || Japanese <ref name="Ali2011" />
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| | Rice bran || 50 || <ref name=Ali2011/>
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| | chicken liver || 48
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| | <ref name="Ali2011" />
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| | Green peas || 46 || <ref name="Ali2011" />
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| | Mango || 30 || <ref name="Ali2011" />
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| | Chickpea || 29 || <ref name="Ali2011" />
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| | Cauliflower (cooked) || 25 || <ref name="Ali2011" />
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| |-
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| | Broccoli (cooked) || 25 || <ref name="Ali2011" />
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| |}
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| == Spermidine and Longevity == | |
| Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice. The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy. | | Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice. The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy. |
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