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== Safety and Dosage == | == Safety and Dosage == | ||
=== Safety === | |||
A 3-month randomized, placebo-controlled, double-blind Phase II trial conducted on older adults with subjective cognitive decline demonstrated that a daily dose of 1.2 mg spermidine was safe and well-tolerated, with no significant differences in vital signs, weight, and clinical chemistry observed between the spermidine and placebo-treated groups<ref name="Schwarz2018">Schwarz C, et al. Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY). 2018 Jan 8;10(1):19-33. doi: 10.18632/aging.101354. PMID: 29315079; PMCID: PMC5807086.</ref>. | |||
=== Dosage === | |||
The optimal dosage for human health and longevity outcomes remains unclear. | |||
== References == | == References == |