Spermidine: Difference between revisions

In a [[Randomized Controlled Trial|randomized controlled trail]] <ref name=":0">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143675/</ref> 15 mg/d of spermidine was administered orally in 12 healthy volunteers for 5 days and the blood levels of spermidine and two related compounds, spermine and putrescine, were measured. Only spermine blood levels increased significantly, but no effect on spermidine or putrescine could be detected. That suggests, when spermidine is taken orally as a supplement, it gets converted into spermine before it enters the bloodstream. This conversion happens presystemically, meaning it occurs before spermidine gets into the systemic circulation. This suggest that the bioavailability of spermidine, in its original form, might be low or perhaps altered, but the compound is still bioavailable in a different form (as spermine) which then has systemic effects.

The optimal dosage for human health and longevity outcomes remains unclear. In a separate study, 15 mg/d of spermidine was administered orally in 12 healthy volunteers for 5 days. Although spermidine was converted into spermine before entering the bloodstream, a significant increase in spermine levels was only observed at the 15 mg daily dose, indicating a threshold dosage for noticeable effects. Lower doses like 0.9-1.2 mg of spermidine per day didn't show changes in blood levels of spermidine, spermine or putrescine, suggesting that a certain amount of spermidine is necessary to see an effect<ref name=":0" />.

 

==References==

<references />