Spermidine: Difference between revisions

Spermidine (view source)

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 == Safety and Dosage ==
-While spermidine supplementation appears to be safe at physiological doses, the optimal dosage for human health and longevity outcomes remains unclear. Most of the current data on spermidine's health benefits come from animal studies, and more comprehensive clinical trials are needed to determine effective dosing strategies for humans.
+=== Safety ===
+A 3-month randomized, placebo-controlled, double-blind Phase II trial conducted on older adults with subjective cognitive decline demonstrated that a daily dose of 1.2 mg spermidine was safe and well-tolerated, with no significant differences in vital signs, weight, and clinical chemistry observed between the spermidine and placebo-treated groups<ref name="Schwarz2018">Schwarz C, et al. Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY). 2018 Jan 8;10(1):19-33. doi: 10.18632/aging.101354. PMID: 29315079; PMCID: PMC5807086.</ref>.
+=== Dosage ===
+The optimal dosage for human health and longevity outcomes remains unclear.
 == References ==