Biomarkers
In the quest to unravel the mysteries of aging and extend human lifespan, biomarkers play a pivotal role. Dr. David Sinclair, a prominent figure in the field of longevity research, has identified a set of biomarkers that are critical to understanding and potentially mitigating the aging process. These biomarkers, which can be measured through blood tests or other medical evaluations, provide insights into the biological state of an individual and are key indicators of one's biological versus chronological age. By monitoring and optimizing these biomarkers, it may be possible to slow the aging process and improve overall healthspan. The following is a summary of what Dr. Sinclair considers the top biomarkers for longevity, emphasizing their importance and impact on aging.
Sinclair's Top 5 Biomarkers For Longevity
| Biomarker | Relevance to Longevity |
|---|---|
| Glucose Level HbA1c | Glycated hemoglobin (HbA1c) levels reflect average blood glucose concentrations over the previous three months. Higher levels are associated with an increased risk of age-related diseases such as diabetes and cardiovascular disease. |
| Inflammatory markers, especially cardiovascular like CRP should be low | Chronic inflammation is linked to many diseases of aging. C-reactive protein (CRP) is a marker of inflammation, and high levels may predict cardiovascular events and mortality. |
| Cholesterol markers including Lipoprotein(a) | Cholesterol levels, particularly low-density lipoprotein (LDL) and lipoprotein(a), are predictors of cardiovascular health. Elevated levels are associated with an increased risk of atherosclerosis and heart disease. |
| Hormone levels (testosterone) | Hormones like testosterone can influence muscle mass, bone density, and overall metabolic health. Low levels in men have been associated with increased morbidity and mortality. |
| Albumin | Albumin levels can indicate nutritional status and organ function. Low albumin may be a marker for poor health outcomes and increased risk of death. |
Todo
- 2023, Correction to: Blood biomarker profiles and exceptional longevity: comparison of centenarians and non‑centenarians in a 35‑year follow‑up of the Swedish AMORIS cohort [1]
- 2021, Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring [2]
References
- ↑ Murata S et al.: Correction to: Blood biomarker profiles and exceptional longevity: comparison of centenarians and non‑centenarians in a 35‑year follow‑up of the Swedish AMORIS cohort. Geroscience 2023. (PMID 37923875) [PubMed] [DOI]
- ↑ Hartmann A et al.: Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring. Front Genet 2021. (PMID 34093670) [PubMed] [DOI] [Full text] Aging affects most living organisms and includes the processes that reduce health and survival. The chronological and the biological age of individuals can differ remarkably, and there is a lack of reliable biomarkers to monitor the consequences of aging. In this review we give an overview of commonly mentioned and frequently used potential aging-related biomarkers. We were interested in biomarkers of aging in general and in biomarkers related to cellular senescence in particular. To answer the question whether a biological feature is relevant as a potential biomarker of aging or senescence in the scientific community we used the PICO strategy known from evidence-based medicine. We introduced two scoring systems, aimed at reflecting biomarker relevance and measurement effort, which can be used to support study designs in both clinical and research settings.