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Bioavailability: Difference between revisions
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==Measuring Bioavailability== | ==Measuring Bioavailability== | ||
Bioavailability is often assessed through specific pharmacokinetic studies, which evaluate the concentration of a drug in plasma over time. Two key metrics used are: | Bioavailability is often assessed through specific pharmacokinetic studies, which evaluate the concentration of a drug in plasma over time. Two key metrics used are: | ||
*'''Absolute Bioavailability''': This measures the bioavailability of a drug compared to its intravenous administration. | *'''Absolute Bioavailability''': This measures the bioavailability of a drug compared to its intravenous administration. It is calculated as the ratio of the [[Area Under the Curve (AUC)|area under the curve (AUC)]] of the plasma concentration-time profile after non-intravenous administration to the AUC after intravenous administration. | ||
*'''Relative Bioavailability''': This compares the bioavailability of a drug in different formulations. | *'''Relative Bioavailability''': This compares the bioavailability of a drug in different formulations. | ||
==Improving Bioavailability== | |||
== Improving Bioavailability== | |||
Research and development in pharmaceutical and nutraceutical sciences focus on enhancing bioavailability through various means: | Research and development in pharmaceutical and nutraceutical sciences focus on enhancing bioavailability through various means: | ||
*'''Advanced Delivery Systems''': Liposomal delivery, microencapsulation, and nanoformulations are designed to protect substances from degradation and enhance absorption. | *'''Advanced Delivery Systems''': Liposomal delivery, microencapsulation, and nanoformulations are designed to protect substances from degradation and enhance absorption. | ||
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Understanding and optimizing bioavailability is fundamental for the effectiveness of drugs and nutritional supplements. As research progresses, new methods and formulations continue to emerge, enhancing the efficacy of therapeutic and nutritional interventions. | Understanding and optimizing bioavailability is fundamental for the effectiveness of drugs and nutritional supplements. As research progresses, new methods and formulations continue to emerge, enhancing the efficacy of therapeutic and nutritional interventions. | ||
== See Also == | ==See Also== | ||
* Wikipedia - [[Wikipedia:Bioavailability|Bioavailability]] | *Wikipedia - [[Wikipedia:Bioavailability|Bioavailability]] | ||