Isoleucine: Difference between revisions

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 [[File:isoleucine Restriction in UM-HET3 mice.jpg|thumb|Isoleucine restriction in UM-HET3 mice<br>(Low ILE = Low isoleucine, Low AA = Low amino acid)]]
 === Isoleucine Restriction ===
-Isoleucine restriction (IleR) has been identified as a significant factor in improving metabolic health and extending lifespan, particularly in genetically heterogeneous UM-HET3 mice. Restricting dietary isoleucine by 67% promotes leanness and glycemic control in both sexes, while also reprogramming hepatic metabolism in a sex-specific manner. Notably, IleR has been observed to reduce frailty and increase the lifespan by 33% of both male and female mice, with more pronounced effects in males. These findings suggest that IleR, or pharmaceuticals that mimic its effects, might serve as a geroprotective intervention, offering potential benefits for healthspan and longevity. The research underscores the importance of isoleucine in diet and aging, and its potential as a target for nutritional and pharmacological interventions in the field of gerontology.{{pmid|37939658}}
+Isoleucine restriction (IleR) has been identified as a significant factor in improving metabolic health and extending lifespan, particularly in genetically heterogeneous mice. Restricting dietary isoleucine by 67% of 9-week-old UM-HET3 mice promotes leanness and glycemic control in both sexes, while also reprogramming hepatic metabolism in a sex-specific manner.
+Most importantly, isoleucine restriction led to a 33% percent increase in median lifespan and to some increase in maximum lifespan in male mice vs controls. This result is one of the most impressive for any intervention ever tested in rodents, especially in HET3 mice. For females, however, the increase in maximum lifespan was only 7%. In accordance with the lifespan results, male mice experienced significantly less frailty. Cancer is the cause of death in more than 80% of HET3 mice. Low Ile males were significantly less likely to get cancer during their lives, but Low Ile females were not.
+These findings suggest that IleR, or pharmaceuticals that mimic its effects, might serve as a geroprotective intervention, offering potential benefits for healthspan and longevity. The research underscores the importance of isoleucine in diet and aging, and its potential as a target for nutritional and pharmacological interventions in the field of gerontology.{{pmid|37939658}}
 == See Also ==