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Genomic Instability: Difference between revisions
→Impact on Aging and Disease
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==Impact on Aging and Disease== | ==Impact on Aging and Disease== | ||
Genomic instability has profound effects on cellular and organismal health: | Genomic instability has profound effects on cellular and organismal health: | ||
*'''Aging''': Accumulation of DNA damage and telomere shortening are strongly associated with the aging process. As cells accumulate genetic damage over time, they lose their functionality and ability to divide, contributing to the aging phenotype. | *'''Aging''': Accumulation of DNA damage and [[Telomere Shortening|telomere shortening]] are strongly associated with the aging process. As cells accumulate genetic damage over time, they lose their functionality and ability to divide, contributing to the aging phenotype. | ||
*'''Cancer''': Genomic instability is a key characteristic of cancer cells, allowing them to acquire mutations that enable uncontrolled growth, invasion, and metastasis. | *'''Cancer''': Genomic instability is a key characteristic of cancer cells, allowing them to acquire mutations that enable uncontrolled growth, invasion, and metastasis. | ||
*'''Neurodegenerative | *'''[[Neurodegenerative Disorders]]''': DNA damage and instability in neurons are linked to various neurodegenerative disorders, such as Alzheimer's and Parkinson's disease. | ||
*'''Immune System Impairment''': Genomic instability can impair the immune system, making the body more susceptible to infections and less efficient at tumor surveillance. | *'''Immune System Impairment''': Genomic instability can impair the immune system, making the body more susceptible to infections and less efficient at tumor surveillance. | ||
==Cellular Response to Genomic Instability== | ==Cellular Response to Genomic Instability== | ||