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Genomic Instability: Difference between revisions
→Causes of Genomic Instability
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*'''DNA Damage''': External and internal factors such as UV radiation, environmental toxins, and metabolic byproducts can cause DNA damage. If unrepaired, this damage can lead to mutations. | *'''DNA Damage''': External and internal factors such as UV radiation, environmental toxins, and metabolic byproducts can cause DNA damage. If unrepaired, this damage can lead to mutations. | ||
*'''Replication Errors''': Errors during DNA replication can introduce mutations. The cellular machinery, while usually accurate, can make mistakes or be influenced by external factors. | *'''Replication Errors''': Errors during DNA replication can introduce mutations. The cellular machinery, while usually accurate, can make mistakes or be influenced by external factors. | ||
*'''Telomere Shortening''': Each cell division leads to a slight shortening of telomeres, the protective caps on the ends of chromosomes. Over time, this can lead to genomic instability as critical DNA sequences may be lost or the chromosome structure may be compromised. | *'''[[Telomere Shortening]]''': Each cell division leads to a slight shortening of telomeres, the protective caps on the ends of chromosomes. Over time, this can lead to genomic instability as critical DNA sequences may be lost or the chromosome structure may be compromised. | ||
*'''Defective DNA Repair Mechanisms''': Cells have intricate DNA repair mechanisms. Defects in these processes can result in an accumulation of DNA damage, contributing to genomic instability. | *'''Defective DNA Repair Mechanisms''': Cells have intricate DNA repair mechanisms. Defects in these processes can result in an accumulation of DNA damage, contributing to genomic instability. | ||
==Impact on Aging and Disease== | ==Impact on Aging and Disease== | ||