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SIRT1: Difference between revisions
→Activation of SIRT1
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The activation of SIRT1 has been a focal point of research due to its potential to extend lifespan and alleviate age-related diseases. Several endogenous and exogenous factors and compounds have been identified to enhance the activity of SIRT1, impacting aging and metabolic health. | The activation of SIRT1 has been a focal point of research due to its potential to extend lifespan and alleviate age-related diseases. Several endogenous and exogenous factors and compounds have been identified to enhance the activity of SIRT1, impacting aging and metabolic health. | ||
==== SIRT1 Activating Compounds (STACs) ==== | |||
Resveratrol is one of the most well-known and studied SIRT1 Activating Compounds (STACs). It is a natural polyphenolic compound found in grapes, berries, peanuts, and red wine. Resveratrol mimics the effects of caloric restriction by modulating the same pathways and has shown to confer protective effects against various diseases, including cardiovascular and neurodegenerative diseases. | |||
In addition to resveratrol, several other synthetic and natural STACs have been identified, such as SRT1720, SRT2104, and quercetin. These compounds have demonstrated the potential to enhance SIRT1 activity, modulate metabolic processes, and extend lifespan in various animal models. The translational potential of these compounds, including resveratrol, to human health and longevity remains to be fully elucidated, with ongoing studies aimed at understanding their efficacy, optimal dosages, and mechanisms of action. | |||
==== Caloric Restriction ==== | ==== Caloric Restriction ==== | ||
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==== Fasting and Intermittent Fasting ==== | ==== Fasting and Intermittent Fasting ==== | ||
Fasting and intermittent fasting, like caloric restriction, create an energy-deprived state that leads to the activation of SIRT1. These dietary strategies have been shown to enhance SIRT1 activity, contributing to improvements in cellular health, metabolism, and longevity. | Fasting and intermittent fasting, like caloric restriction, create an energy-deprived state that leads to the activation of SIRT1. These dietary strategies have been shown to enhance SIRT1 activity, contributing to improvements in cellular health, metabolism, and longevity. | ||