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Quercetin: Difference between revisions
→Enhancing Bioavailability
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Due to inherent limitations in bioavailability, several strategies have been explored to enhance the absorption and stability of quercetin. These include the development of various formulations and delivery systems such as: | Due to inherent limitations in bioavailability, several strategies have been explored to enhance the absorption and stability of quercetin. These include the development of various formulations and delivery systems such as: | ||
{| class="wikitable" | {| class="wikitable" style="width:100%; text-align:center;" | ||
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!Formulation!! | ! Formulation !! Enhancement in Bioavailability !! Solubility in Water !! Appearance !! Notes | ||
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|Quercetin | | Standard Quercetin || 1 (baseline) || Very Low || Yellow crystalline powder || Naturally occurring in various plants; serves as the baseline form of quercetin with poor solubility and bioavailability. | ||
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| | | Quercetin Phytosomes || Up to 20 times || Low || Yellow to brownish powder || Significantly increases oral bioavailability compared to standard quercetin. | ||
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| | | Nanoparticle Formulations || Several-fold increase || Variable, generally improved || Nano-sized particles; appearance may vary || Includes liposomal encapsulations; increased solubility and cellular uptake. | ||
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| | | Complexation with Cyclodextrins || Up to 10 times || Enhanced || White to off-white powder || Improves water solubility significantly, enhancing therapeutic effects. | ||
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| Co-administration with Piperine || Approximately 20% || Low || Yellow crystalline powder (Quercetin); White to off-white powder (Piperine) || Inhibits metabolism of quercetin, improving its bioavailability. | |||
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| Quercetin Dihydrate || – || Moderate || Yellow to orange crystalline powder || Synthetic form with two water molecules associated; usually preferred for dietary supplements due to improved solubility. | |||
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| Anhydrous Quercetin || – || Very Low || Yellow crystalline powder || Used in formulations where the presence of water is undesirable; has lower solubility compared to its hydrated form. | |||
|} | |} | ||