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Quercetin: Difference between revisions
→Quercetin Phytosome
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In the clinical study, a ~20-fold increase in bioavailability was measured compared to standard quercetin with equal doses. Given that Quercetin Phytosome contains ~40% and has a ~20 fold relative bioavailability, one can assume that the total bioavailability of standard quercetin is less than 2%. | In the clinical study, a ~20-fold increase in bioavailability was measured compared to standard quercetin with equal doses. Given that Quercetin Phytosome contains ~40% and has a ~20 fold relative bioavailability, one can assume that the total bioavailability of standard quercetin is less than 2%. | ||
{| class="wikitable" | |||
|+Pharmacokinetic parameters | |||
! | |||
!Quercetin 500 mg | |||
!Quercetin Phytosome 500 mg | |||
!Quercetin Phytosome 250 mg | |||
|- | |||
|AUClast (min × ng/ml) | |||
| colspan="1" rowspan="1" |4774.93 ± 1190.61 | |||
| colspan="1" rowspan="1" |96,163.87 ± 9291.31 | |||
| colspan="1" rowspan="1" |50,401.53 ± 6418.22 | |||
|- | |||
| colspan="1" rowspan="1" |Cmax (ng/ml) | |||
| colspan="1" rowspan="1" |10.93 ± 2.22 | |||
| colspan="1" rowspan="1" |223.10 ± 16.32 | |||
| colspan="1" rowspan="1" |126.35 ± 14.79* | |||
|- | |||
| colspan="1" rowspan="1" |Tmax (min) | |||
| colspan="1" rowspan="1" |290.00 ± 31.19 | |||
| colspan="1" rowspan="1" |202.50 ± 35.97 | |||
| colspan="1" rowspan="1" |228.75 ± 36.61 | |||
|- | |||
| colspan="1" rowspan="1" |''t''1/2 (min) | |||
| colspan="1" rowspan="1" |375.63 ± 75.51 | |||
| colspan="1" rowspan="1" |226.84 ± 8.13 | |||
| colspan="1" rowspan="1" |201.63 ± 13.18 | |||
|- | |||
| colspan="1" rowspan="1" |MRT last (min) | |||
| colspan="1" rowspan="1" |410.41 ± 24.24 | |||
| colspan="1" rowspan="1" |372.94 ± 20.12 | |||
| colspan="1" rowspan="1" |386.29 ± 21.04 | |||
|} | |||
Quercetin Phytosome overcomes the low bioavailability hurdle of quercetin and should help to fulfill the great health benefit potential of this flavonoid in the diet and as food supplements. | Quercetin Phytosome overcomes the low bioavailability hurdle of quercetin and should help to fulfill the great health benefit potential of this flavonoid in the diet and as food supplements. | ||