Resveratrol: Difference between revisions

A recent study <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346321/</ref> expanded our understanding of resveratrol's role as a caloric restriction mimetic. In a [[Randomized Controlled Trial|randomized trial]] involving healthy adults aged 55 to 65, resveratrol supplementation were compared to the effects of a caloric-restricted diet. demonstrated a capacity to , comparable to the effects of a caloric-restricted diet. Both interventions increase circulating SIRT1 levels and also led to a significant reduction in plasma noradrenaline, indicating a decrease in sympathetic nervous system activity, which is beneficial for cardiovascular health. However, while resveratrol and caloric restriction similarly increased SIRT1 levels, the study unveiled disparities in vascular reactivity between the groups. Post-treatment circulating SIRT1 was associated with improvements in nitrate-mediated vasodilation (NMD) only in the caloric restriction group, not in the resveratrol group. Furthermore, SIRT1 predicted improvements in flow-mediated vasodilation (FMD) in men but not in women, suggesting potential sex-specific vascular responses to SIRT1 modulation. These findings underscore that although resveratrol mimics several effects of caloric restriction and positively modulates factors associated with cardiovascular health, it may not replicate all the vascular benefits of energy restriction. The data indicate the existence of additional mechanisms activated by caloric restriction, possibly involving inflammation modulation, endothelial function, or other molecular pathways, that are not directly triggered by resveratrol.